Summary

Name ITGAM
Full Name Integrin alpha-M
Synonyms CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor | CD11B, CR3A
Primary ID P11215
Links - -
Type protein
Relations 6
Pathways Neutrophils: Adhesion and migration
Function Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:9558116, PubMed:20008295). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png ITGAM 0.302
Publications: 1
+ form complex img/form-complex.png binding AM/b2 integrin 0.742
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ITGAM 0.565
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ICAM1 0.765
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png ITGAM 0.384
Publications: 1
+ up-regulates img/indirect-activation.png Differentiation 0.7
Publications: 1 Organism: Homo Sapiens