| + |
PRKAA1 | down-regulates activity 
phosphorylation
|
PRPS2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265731 |
Ser180 |
GGAKRVTsIADRLNV |
Homo sapiens |
LK-87 Cell |
| pmid |
sentence |
| 29074724 |
We demonstrate here that glucose deprivation or hypoxia results in the AMPK-mediated phosphorylation of phosphoribosyl pyrophosphate synthetase 1 (PRPS1) S180 and PRPS2 S183, leading to conversion of PRPS hexamers to monomers and thereby inhibiting PRPS1/2 activity, nucleotide synthesis, and nicotinamide adenine dinucleotide (NAD) production. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMPK | down-regulates activity
phosphorylation
|
PRPS2 |
0.244 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265732 |
Ser180 |
GGAKRVTsIADRLNV |
Homo sapiens |
LK-87 Cell |
| pmid |
sentence |
| 29074724 |
We demonstrate here that glucose deprivation or hypoxia results in the AMPK-mediated phosphorylation of phosphoribosyl pyrophosphate synthetase 1 (PRPS1) S180 and PRPS2 S183, leading to conversion of PRPS hexamers to monomers and thereby inhibiting PRPS1/2 activity, nucleotide synthesis, and nicotinamide adenine dinucleotide (NAD) production. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TBK1 | up-regulates activity 
phosphorylation
|
PRPS2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277317 |
Thr228 |
DMADTCGtICHAADK |
in vitro |
|
| pmid |
sentence |
| 34343500 |
Here, we show that ionizing radiation results in TBK1-mediated phosphorylation of phosphoribosyl pyrophosphate synthetase (PRPS)1/2 at T228, thereby enhancing PRPS1/2 catalytic activity and promoting deoxyribonucleotide synthesis. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
LATS2 | down-regulates quantity by destabilization
phosphorylation
|
PRPS2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276507 |
Thr285 |
EDKMKHCtKIQVIDI |
in vitro |
|
| pmid |
sentence |
| 34465890 |
Recruitment of TRAF2 to PRPS1/2 requires phosphorylation of PRPS1 S285 or PRPS2 T285, which is mediated by low stiffness-activated large tumor suppressor (LATS)1/2 kinases.LATS1/2-dependent S/T285 phosphorylation is required for PRPS1/2 ubiquitination and degradation at low stiffness. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
LATS1 | down-regulates quantity by destabilization
phosphorylation
|
PRPS2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276506 |
Thr285 |
EDKMKHCtKIQVIDI |
in vitro |
|
| pmid |
sentence |
| 34465890 |
Recruitment of TRAF2 to PRPS1/2 requires phosphorylation of PRPS1 S285 or PRPS2 T285, which is mediated by low stiffness-activated large tumor suppressor (LATS)1/2 kinases.LATS1/2-dependent S/T285 phosphorylation is required for PRPS1/2 ubiquitination and degradation at low stiffness. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PRPS2 | down-regulates quantity
chemical modification
|
D-ribofuranose 5-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267081 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16939420 |
PRPP (phosphoribosylpyrophosphate) is an important metabolite essential for nucleotide synthesis and PRS (PRPP synthetase) catalyses synthesis of PRPP from R5P (ribose 5-phosphate) and ATP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Pentose phosphate pathway |
| + |
PRPS2 | up-regulates 
|
Nucleotide_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265734 |
|
|
Homo sapiens |
LK-87 Cell |
| pmid |
sentence |
| 29074724 |
We demonstrate here that glucose deprivation or hypoxia results in the AMPK-mediated phosphorylation of phosphoribosyl pyrophosphate synthetase 1 (PRPS1) S180 and PRPS2 S183, leading to conversion of PRPS hexamers to monomers and thereby inhibiting PRPS1/2 activity, nucleotide synthesis, and nicotinamide adenine dinucleotide (NAD) production. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Pentose phosphate pathway |
| + |
PRPS2 | up-regulates quantity
chemical modification
|
5-phospho-α-D-ribose 1-diphosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267082 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16939420 |
PRPP (phosphoribosylpyrophosphate) is an important metabolite essential for nucleotide synthesis and PRS (PRPP synthetase) catalyses synthesis of PRPP from R5P (ribose 5-phosphate) and ATP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Pentose phosphate pathway |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
PRPS2 |
0.281 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267376 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18677108 |
Analysis of in vivo C-MYC interactions with TS, IMPDH2 and PRPS2 genes confirmed that they are direct C-MYC targets. C-MYC depletion did not significantly affect levels of E2F1 protein reported to regulate expression of many S-phase specific genes, but resulted in the repression of several genes encoding enzymes rate-limiting for dNTP metabolism. These included thymidylate synthase (TS), inosine monophosphate dehydrogenase 2 (IMPDH2) and phosphoribosyl pyrophosphate synthetase 2 (PRPS2). C-MYC depletion also resulted in reduction in the amounts of deoxyribonucleoside triphosphates (dNTPs) and inhibition of proliferation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Pentose phosphate pathway |
3.0
PRPS2
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