3.0
Summary
| Name |  CD79AView Modifications |
| Full Name | B-cell antigen receptor complex-associated protein alpha chain |
| Synonyms | Ig-alpha, MB-1 membrane glycoprotein, Membrane-bound immunoglobulin-associated protein, Surface IgM-associated protein | IGA, MB1 |
| Primary ID | P11912 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Pathways | B-cell activation |
| Function | Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | LYN | up-regulates activity 
phosphorylation
|
CD79A | 0.728 |
| Publications: | 1 | Organism: | In Vitro | |
| Pathways: | B-cell activation | |||
| + | FYN | up-regulates activity
phosphorylation
|
CD79A | 0.575 |
| Publications: | 1 | Organism: | In Vitro | |
| Pathways: | B-cell activation | |||
| + | CD79A | down-regulates quantity by repression 
transcriptional regulation
|
BCL2L1 | 0.274 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CD79A | form complex 
binding
|
BCR-Ml | 0.637 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | B-cell activation | |||
| + | CD79A | form complex
binding
|
BCR-Mk | 0.637 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | B-cell activation | |||
| + | CHD4 | down-regulates quantity by repression
transcriptional regulation
|
CD79A | 0.253 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | CD79A | form complex
binding
|
BCR-Dl | 0.637 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | B-cell activation | |||
| + | CD79A | form complex
binding
|
BCR-Dk | 0.637 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | B-cell activation | |||
| + | SH2B1 | down-regulates activity 
dephosphorylation
|
CD79A | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | B-cell activation | |||