Summary

Name PTHLH
Full Name Parathyroid hormone-related protein
Synonyms PTH-rP, PTHrP, Parathyroid hormone-like protein, PLP | PTHRP
Primary ID P12272
Links - -
Type protein
Relations 6
Function Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png cleavage PTHLH 0.434
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation PTHLH 0.381
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PTHLH 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PTH1R 0.753
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding PTHLH 0.434
Publications: 1 Organism: In Vitro