| + |
ASB9 | down-regulates quantity by destabilization 
polyubiquitination
|
CKB |
0.705 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271623 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17148442 |
We demonstrate that creatine kinase B (CKB) interacts with Asb-9 in a specific, SOCS box-independent manner. This interaction increases the polyubiquitylation of CKB and decreases total CKB levels within the cell. The targeting of CKB for degradation by Asb-9 was primarily SOCS box-dependent and suggests that Asb-9 acts as a specific ubiquitin ligase regulating levels of this evolutionarily conserved enzyme. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CKB | up-regulates quantity 
relocalization
|
ACTB |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265791 |
|
|
Homo sapiens |
Astrocyte |
| pmid |
sentence |
| 19333390 |
In summary, data presented here strongly suggest that locally generated ATP is an important regulator for actin-based cytoskeletal dynamics involved in cell extension and motility and that CK-B is a controlling enzyme in the compartmentalization of ATP availability. CK-B co-localizes with cortical actin and facilitates spreading of astrocytes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
creatine | up-regulates activity
chemical activation
|
CKB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265809 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18502307 |
Creatine kinase catalyses the reversible transphosphorylation of creatine by ATP. In the cell, creatine kinase isoenzymes are specifically localized at strategic sites of ATP consumption to efficiently regenerate ATP in situ via phosphocreatine or at sites of ATP generation to build-up a phosphocreatine pool. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265783 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18502307 |
Creatine kinase catalyses the reversible transphosphorylation of creatine by ATP. In the cell, creatine kinase isoenzymes are specifically localized at strategic sites of ATP consumption to efficiently regenerate ATP in situ via phosphocreatine or at sites of ATP generation to build-up a phosphocreatine pool. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CKB | up-regulates quantity
chemical modification
|
N-phosphocreatine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265787 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18502307 |
Creatine kinase catalyses the reversible transphosphorylation of creatine by ATP. In the cell, creatine kinase isoenzymes are specifically localized at strategic sites of ATP consumption to efficiently regenerate ATP in situ via phosphocreatine or at sites of ATP generation to build-up a phosphocreatine pool. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CKB
- 
- 