Summary

Name TDGF1
Full Name Teratocarcinoma-derived growth factor 1
Synonyms Cripto-1 growth factor, CRGF, Epidermal growth factor-like cripto protein CR1 | CRIPTO
Primary ID P13385
Links - -
Type protein
Relations 10
Function GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed:11909953).

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TDGF1 0.673
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png MSTN 0.316
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding ACVR2A 0.627
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TDGF1 0.644
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TDGF1 0.621
Publications: 1
+ down-regulates activity img/direct_inhibition.png binding TGFB1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TDGF1 0.515
Publications: 1
+ up-regulates img/indirect-activation.png Skeletal_muscle_differentiation 0.7
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates activity img/direct-activation.png binding ACVR1B 0.716
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NODAL 0.644
Publications: 1 Organism: Homo Sapiens