Summary

Name ACVR2A
Full Name Activin receptor type-2A
Synonyms Activin receptor type IIA, ACTR-IIA, ACTRIIA | ACVR2
Primary ID P27037
Links - -
Type protein
Relations 5
Pathways Multiple sclerosis
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ TDGF1down-regulates img/direct_inhibition.png binding ACVR2A 0.626
Publications: 1 Organism: Homo Sapiens
+ BMP7up-regulates img/direct-activation.png binding ACVR2A 0.76
Publications: 1 Organism: Homo Sapiens
+ ACVR2Aup-regulates img/direct-activation.png phosphorylation ACVR1B 0.667
Publications: 1 Organism: Homo Sapiens
Pathways:Multiple sclerosis
+ INHBAup-regulates activity img/direct-activation.png binding ACVR2A 0.805
Publications: 1 Organism: Homo Sapiens
Pathways:Multiple sclerosis
+ ACVR2Aup-regulates img/direct-activation.png binding ACVR1 0.644
Publications: 1 Organism: Homo Sapiens