| + |
GDNF | up-regulates activity 
binding
|
NCAM1 |
0.688 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252189 |
|
|
Rattus norvegicus |
Neural Stem Cell |
| pmid |
sentence |
| 15212950 |
Recently, NCAM was identified as an alternative receptor for GDNF. These new results may explain the findings that, in several regions, the GDNF receptor (GFRa1) is highly expressed, while RET is undetectable. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
ALX4 | down-regulates quantity by repression 
transcriptional regulation
|
NCAM1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254548 |
|
|
Mus musculus |
Mesenchymal Stromal Cell |
| pmid |
sentence |
| 11696550 |
Alx4 Overexpression Represses Endogenous N-CAM Expression |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
LEF1 | up-regulates activity 
transcriptional regulation
|
NCAM1 |
0.279 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254549 |
|
|
Mus musculus |
Mesenchymal Stromal Cell |
| pmid |
sentence |
| 11696550 |
Consistent with our observation that expression of exogenous LEF-1 causes transactivation of the N-CAM promoter, a recent study demonstrated that noggin-dependent induction of LEF-1 coincidentally increased N-CAM expression (50). Ectopic noggin added to skin cultures up-regulates LEF-1 expression and stimulates hair induction. Based on promoter assays and EMSAs, our results further support the notion that N-CAM is a direct target of LEF-1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
NCAM1
- 
- 