3.0
Summary
| Name |  UCHL3View Modifications |
| Full Name | Ubiquitin carboxyl-terminal hydrolase isozyme L3 |
| Synonyms | UCH-L3, Ubiquitin thioesterase L3 | |
| Primary ID | P15374 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Pathways | Ubiquitin activation |
| Function | Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. |
Viewer
Search Tools
Refine search:
- by mechanism
- by effect
- by organism:
- by tissue:
- by cell-line
Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | UCHL3 | up-regulates activity 
deubiquitination
|
RAD51 | 0.33 |
| Publications: | 3 | |||
| + | ATM | up-regulates activity
phosphorylation
|
UCHL3 | 0.335 |
| Publications: | 1 | |||
| + | UCHL3 | up-regulates quantity
cleavage
|
Ubiquitin | 0.864 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Ubiquitin activation | |||
| + | UCHL3 | up-regulates quantity
cleavage
|
RPS27A | 0.789 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Ubiquitin activation | |||
| + | UCHL3 | up-regulates quantity
cleavage
|
UBA52 | 0.788 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Ubiquitin activation | |||