| + |
UCHL3 | up-regulates activity 
deubiquitination
|
RAD51 |
0.324 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275907 |
Lys57 |
EAVAYAPkKELINIK |
|
|
| pmid |
sentence |
| 27941124 |
Here we report that ubiquitination of RAD51 hinders RAD51-BRCA2 interaction, while deubiquitination of RAD51 facilitates RAD51-BRCA2 binding and RAD51 recruitment and thus is critical for proper HR. | UCHL3, in turn, deubiquitinates RAD51 and promotes the binding between RAD51 and BRCA2.|Our results suggested that three lysine sites (56, 57, and 63) on RAD51 that are close to E59 are deubiquitinated by UCHL3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275908 |
Lys58 |
AVAYAPKkELINIKG |
|
|
| pmid |
sentence |
| 27941124 |
Here we report that ubiquitination of RAD51 hinders RAD51-BRCA2 interaction, while deubiquitination of RAD51 facilitates RAD51-BRCA2 binding and RAD51 recruitment and thus is critical for proper HR. | UCHL3, in turn, deubiquitinates RAD51 and promotes the binding between RAD51 and BRCA2.|Our results suggested that three lysine sites (56, 57, and 63) on RAD51 that are close to E59 are deubiquitinated by UCHL3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275909 |
Lys64 |
KKELINIkGISEAKA |
|
|
| pmid |
sentence |
| 27941124 |
Here we report that ubiquitination of RAD51 hinders RAD51-BRCA2 interaction, while deubiquitination of RAD51 facilitates RAD51-BRCA2 binding and RAD51 recruitment and thus is critical for proper HR. | UCHL3, in turn, deubiquitinates RAD51 and promotes the binding between RAD51 and BRCA2.|Our results suggested that three lysine sites (56, 57, and 63) on RAD51 that are close to E59 are deubiquitinated by UCHL3. |
|
| Publications: |
3 |
| + |
ATM | up-regulates activity
phosphorylation
|
UCHL3 |
0.329 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275910 |
Ser75 |
EEEEKIKsQGQDVTS |
|
|
| pmid |
sentence |
| 27941124 |
The deubiquitinase UCHL3 is phosphorylated and activated by ATM. UCHL3, in turn, deubiquitinates RAD51 and promotes the binding between RAD51 and BRCA2. |Mutation of S75 (S75A) abolished the pSQ/TQ signal, suggesting that S75 is a major ATM phosphorylation site following DNA damage |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279794 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27941124 |
Mechanistically, in response to DNA damage, the deubiquitinase UCHL3 is phosphorylated and activated by ATM. |
|
| Publications: |
2 |
Organism: |
, Homo Sapiens |
| + |
UCHL3 | up-regulates quantity
cleavage
|
UBA52 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270827 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 26235645 |
Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Ubiquitin activation |
| + |
UCHL3 | up-regulates quantity
cleavage
|
Ubiquitin |
0.871 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270832 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 26235645 |
Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Ubiquitin activation |
| + |
UCHL3 | up-regulates quantity
cleavage
|
RPS27A |
0.801 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270828 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 26235645 |
Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Ubiquitin activation |
4.0
UCHL3
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