+ |
PRKACA | down-regulates activity
phosphorylation
|
DSP |
0.334 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-250353 |
Ser2849 |
RSGSRRGsFDATGNS |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
7525582 |
HeLa cells treated with forskolin indicated that stimulation of protein kinase A in transfected cells could decrease the interaction of DP.AN.SerC23 with keratin IF networks. phosphorylation of Ser-C23 could destabilize interactions that occur either directly through this 20 residue sequence or that are dependent on its correct conformation |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PKP2 | up-regulates quantity by stabilization
binding
|
DSP |
0.778 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261254 |
|
|
Mus musculus |
HL-1 Cell |
pmid |
sentence |
22781308 |
In contrast to the proper membrane localization of PKP2 and DSP after cotransfection of both WT proteins, mutant PKP2 C796R protein was not able to interact with FLAG-DSP to enable assembly at the junctional plaque, indicating the requirement of functional PKP2 for DSP integration into the desmosome. |
|
Publications: |
1 |
Organism: |
Mus Musculus |