| + |
ZEB2 | down-regulates quantity by repression 
transcriptional regulation
|
PKP2 |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281185 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16314317 |
SIP1/ZEB2 is a member of the δEF-1 family of two-handed zinc finger nuclear factors. The expression of these transcription factors is associated with epithelial mesenchymal transitions (EMT) during development. we could demonstrate physical interaction at the chromatin level between SIP1 and the promoter regions of E-cadherin, plakophilin 2, connexin 26 and ZO-3, all of which contain SIP1-binding sites. Hence, we have to conclude that E-cadherin and other junctional genes are simultaneously downregulated as part of the SIP1 driven reprogramming during EMT. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PKP2 | down-regulates 
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281188 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16314317 |
SIP1/ZEB2 is a member of the δEF-1 family of two-handed zinc finger nuclear factors. Here, we show that expression of SIP1 in human epithelial cells results in a clear morphological change from an epithelial to a mesenchymal phenotype. Induction of this epithelial dedifferentiation was accompanied by repression of several cell junctional proteins, with concomitant repression of their mRNA levels. The expression of these transcription factors is associated with epithelial mesenchymal transitions (EMT) during development. we could demonstrate physical interaction at the chromatin level between SIP1 and the promoter regions of E-cadherin, plakophilin 2, connexin 26 and ZO-3, all of which contain SIP1-binding sites. Hence, we have to conclude that E-cadherin and other junctional genes are simultaneously downregulated as part of the SIP1 driven reprogramming during EMT. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PKP2 | up-regulates quantity by stabilization 
binding
|
DSP |
0.788 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261254 |
|
|
Mus musculus |
HL-1 Cell |
| pmid |
sentence |
| 22781308 |
In contrast to the proper membrane localization of PKP2 and DSP after cotransfection of both WT proteins, mutant PKP2 C796R protein was not able to interact with FLAG-DSP to enable assembly at the junctional plaque, indicating the requirement of functional PKP2 for DSP integration into the desmosome. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
4.0
PKP2
- 
- 