| + |
EN2 | down-regulates quantity by repression 
transcriptional regulation
|
FGF8 |
0.428 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265801 |
|
|
Mus musculus |
CCE Cell |
| pmid |
sentence |
| 10026229 |
Our results in ES cells suggest that Engrailed inhibits Fgf8 expression in the absence of Pbx1. We identified single Engrailed- and Pbx-binding sites in the Fgf8 intron that inhibit expression of Fgf8 in mouse ES cells, but that together can allow full Fgf8 expression. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265775 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 10026229 |
Our results in ES cells suggest that Engrailed inhibits Fgf8 expression in the absence of Pbx1. We identified single Engrailed- and Pbx-binding sites in the Fgf8 intron that inhibit expression of Fgf8 in mouse ES cells, but that together can allow full Fgf8 expression. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
HNuRF | up-regulates quantity by expression 
|
EN2 |
0.308 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268840 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14609955 |
Human NURF (hNURF) is enriched in brain, and we demonstrate that it regulates human Engrailed, a homeodomain protein that regulates neuronal development in the mid-hindbrain. Furthermore, we show that hNURF potentiates neurite outgrowth in cell culture. Taken together, our data suggess a role for an ISWI complex in neuronal growth. ) ChIP assays localize hNURF specifically to engrailed-1 (en-1) and engrailed-2 (en-2) promoters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
EN2
- 
- 