Summary

Name EIF2S2
Full Name Eukaryotic translation initiation factor 2 subunit 2
Synonyms Eukaryotic translation initiation factor 2 subunit beta, eIF-2-beta | EIF2B
Primary ID P20042
Links - -
Type protein
Relations 10
Function eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation EIF2S2 0.355
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor EIF2S2 0.739
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png translation regulation EGLN1 0.2
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Ternary_GTP_eIF2_tRNA_complex 0.953
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor EIF2S2 0.872
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor EIF2S2 0.768
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor EIF2S2 0.743
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor EIF2S2 0.841
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding EIF2S2 0.743
Publications: 1 Organism: Homo Sapiens