| + |
ATM | up-regulates 
phosphorylation
|
HNF1A |
0.259 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205087 |
Ser249 |
IQRGVSPsQAQGLGS |
Homo sapiens |
|
| pmid |
sentence |
| 24821553 |
Serine 249 phosphorylation by atm protein kinase regulates hepatocyte nuclear factor-1_ transactivation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DYRK1B | up-regulates
phosphorylation
|
HNF1A |
0.516 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-86728 |
Ser249 |
IQRGVSPsQAQGLGS |
Homo sapiens |
|
| pmid |
sentence |
| 11980910 |
Mirk phosphorylates hnf1 at amino acid 249mkk3 enhanced mirk kinase activity and the transcriptional activation of hnf1alpha by mirk |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
HOXC11 | up-regulates 
|
HNF1A |
0.312 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-57484 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9582375 |
The observed stimulatory effect of hoxc11 on hnf1_ may be due to a similar stabilizing effect on hnf1_ dna binding and/or an increase in transcriptional activity of hnf1_. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
SLC22A10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268983 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 20829431 |
Luciferase reporter gene constructs containing the OAT5 (SLC22A10) and OAT7 (SLC22A9) promoter regions were transactivated by HNF-1 in HepG2 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
AFP |
0.336 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254447 |
|
|
Homo sapiens |
HEP-3B Cell |
| pmid |
sentence |
| 9792724 |
AFP promoter-chloramphenicol acetyltransferase transient transfection assays demonstrated that the level of HNF1 had a direct impact on basal transcription as well as RA-mediated down-regulation of the AFP gene, and that co-transfection of HNF1 and HNF4, but not transfection of either factor alone, reversed the RA-mediated inhibition. Taken together these data point to an interaction among the RA, HNF1, and HNF4 signals, which is reflected in decreased expression of AFP. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254637 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 7549116 |
HNF-1 beta was found to be more potent than HNF-1 alpha in activating the AFP promoter in the HepG2 cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254435 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11314020 |
We investigated AFP gene regulation in AFP-GC by an active transcription factor, HNF1 (hepatocyte nuclear factor 1) and a repressive transcription factor, ATBF1 (AT motif binding factor 1). CAT assays showed the direct inhibition of AFP gene expression by ATBF1. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
SLC22A9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268982 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 20829431 |
Luciferase reporter gene constructs containing the OAT5 (SLC22A10) and OAT7 (SLC22A9) promoter regions were transactivated by HNF-1 in HepG2 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
UGT1A8 |
0.284 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253972 |
|
|
Homo sapiens |
CACO-2 Cell |
| pmid |
sentence |
| 15044625 |
Using gel shift and functional assays, HNF1alpha was demonstrated to bind to and activate the UGT1A8, -1A9, and -1A10 promoters. In contrast, Cdx2 bound to and activated the UGT1A8 and -1A10 promoters but could not activate the UGT1A9 promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
CDH17 |
0.318 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253970 |
|
|
Homo sapiens |
HEP-3B Cell, MHCC-97 Cell |
| pmid |
sentence |
| 20568120 |
The present study aims to identify the transcription factors which interact and regulate CDH17 promoter activity that might contribute to the up-regulation of CDH17 gene in human HCC|we identified hepatic nuclear factor 1α (HNF1α) and caudal-related homeobox 2 (CDX2) binding sites at the proximal promoter region which modulate the CDH17 promoter activities in two HCC cell lines (Hep3B and MHCC97L) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
UGT1A10 |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253971 |
|
|
Homo sapiens |
CACO-2 Cell |
| pmid |
sentence |
| 15044625 |
Using gel shift and functional assays, HNF1alpha was demonstrated to bind to and activate the UGT1A8, -1A9, and -1A10 promoters. In contrast, Cdx2 bound to and activated the UGT1A8 and -1A10 promoters but could not activate the UGT1A9 promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
UGT1A9 |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253973 |
|
|
Homo sapiens |
CACO-2 Cell |
| pmid |
sentence |
| 15044625 |
Using gel shift and functional assays, HNF1alpha was demonstrated to bind to and activate the UGT1A8, -1A9, and -1A10 promoters. In contrast, Cdx2 bound to and activated the UGT1A8 and -1A10 promoters but could not activate the UGT1A9 promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
IGF1 |
0.306 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251720 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10050749 |
Growth hormone induces insulin-like growth factor-I gene transcription by a synergistic action of STAT5 and HNF-1α |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
ALDOB |
0.316 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253834 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8383844 |
Contransfection experiments of aldolase B/CAT constructs and of expression vectors for different transcription factors were carried out in human hepatoma Hep G2 cells. We found that DBP and HNF-1 are strong transactivators of the aldolase B promoter while C/EBP and vHNF-1 are only weak activators |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
SLCO1B3 |
0.254 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268988 |
|
|
|
|
| pmid |
sentence |
| 16741617 |
Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene.|This study demonstrated that the transcription of the LST-2 gene is regulated by three transcription factors, FXR, HNF1alpha, and HNF3beta. |
|
| Publications: |
1 |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
AKR1C4 |
0.248 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-239964 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2044952 |
Hepatocyte nuclear factor (HNF)-4_/_, HNF-1_, and vHNF-1 regulate the cell-specific expression of the human dihydrodiol dehydrogenase (DD)4/AKR1C4 gene. HNF-1_ binds to the target element in the rat DBP gene in the liver, while vHNF-1 recognizes a target element in extrahepatic tissues. The ability of vHNF-1-A to activate the rat DBP gene is much higher than that of vHNF-1-C. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
Aldolase |
0.316 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270224 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 8383844 |
Contransfection experiments of aldolase B/CAT constructs and of expression vectors for different transcription factors were carried out in human hepatoma Hep G2 cells. We found that DBP and HNF-1 are strong transactivators of the aldolase B promoter while C/EBP and vHNF-1 are only weak activators |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
UGT1A1 |
0.285 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254437 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18172616 |
This study indicates that hepatocyte nuclear factor 1alpha (HNF1alpha) bound to the proximal promoter motif not only enhances the basal reporter activity of UGT1A1, including the distal (-3570/-3180) and proximal (-165/-1) regions, but also influences the transcriptional regulation of UGT1A1 by CAR, PXR, GR, and AhR to markedly enhance reporter activities. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
HNF1A
- 
- 