| + |
STAT5A | up-regulates quantity by expression 
transcriptional regulation
|
SLCO1B3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268990 |
|
|
|
|
| pmid |
sentence |
| 15840840 |
PRL enhanced the binding of Stat5a to the OATP1B3 promoter and DNA-protein binding was inhibited in competition assays by excess OATP1B3 and Stat5 consensus oligomers but not by mutant Stat5 oligomers.|PRL and GH induction of Oatp1b2 and OATP1B3 promoter activity required cotransfection of Stat5a and PRLRL or GHR. |
|
| Publications: |
1 |
| + |
CEBPG | up-regulates quantity by expression
transcriptional regulation
|
SLCO1B3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268986 |
|
|
|
|
| pmid |
sentence |
| 15322262 |
Taken together, these findings suggest that the LPS-induced down-regulation of Oatp4 is likely due to reduction in the binding of HNF1alpha, C/EBP, HNF3, and RXR:RAR to the Oatp4 promoter. |
|
| Publications: |
1 |
| + |
FOXA2 | down-regulates quantity by repression 
transcriptional regulation
|
SLCO1B3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268987 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14739090 |
The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RARA | up-regulates quantity by expression
transcriptional regulation
|
SLCO1B3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268989 |
|
|
|
|
| pmid |
sentence |
| 15322262 |
Taken together, these findings suggest that the LPS-induced down-regulation of Oatp4 is likely due to reduction in the binding of HNF1alpha, C/EBP, HNF3, and RXR:RAR to the Oatp4 promoter. |
|
| Publications: |
1 |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
SLCO1B3 |
0.255 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268988 |
|
|
|
|
| pmid |
sentence |
| 16741617 |
Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene.|This study demonstrated that the transcription of the LST-2 gene is regulated by three transcription factors, FXR, HNF1alpha, and HNF3beta. |
|
| Publications: |
1 |
3.0
SLCO1B3
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