4.0
Summary
| Name |  ACO1View Modifications |
| Full Name | Cytoplasmic aconitate hydratase |
| Synonyms | Aconitase, Citrate hydro-lyase, Ferritin repressor protein, Iron regulatory protein 1, IRP1, Iron-responsive element-binding protein 1, IRE-BP 1 | IREB1 |
| Primary ID | P21399 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Pathways | Citric acid cycle - Krebs cycle |
| Function | Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCA | down-regulates 
phosphorylation
|
ACO1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Kidney | |||
| + | ACO1 | down-regulates quantity
chemical modification
|
citrate(3-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Citric acid cycle - Krebs cycle | |||
| + | ACO1 | up-regulates quantity 
chemical modification
|
D-threo-isocitrate(3-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Citric acid cycle - Krebs cycle | |||