Summary

Name ACO1
Full Name Cytoplasmic aconitate hydratase
Synonyms Aconitase, Citrate hydro-lyase, Ferritin repressor protein, Iron regulatory protein 1, IRP1, Iron-responsive element-binding protein 1, IRE-BP 1 | IREB1
Primary ID P21399
Links - -
Type protein
Relations 3
Pathways Citric acid cycle
Function Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation ACO1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates quantity img/direct-activation.png chemical modification D-threo-isocitrate(3-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Citric acid cycle
+ down-regulates quantity img/direct_inhibition.png chemical modification citrate(3-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Citric acid cycle