Summary

Name FPR1
Full Name fMet-Leu-Phe receptor
Synonyms fMLP receptor, N-formyl peptide receptor, FPR, N-formylpeptide chemoattractant receptor
Primary ID P21462
Links - -
Type protein
Relations 12
Function High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456). Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (PubMed:25109685).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation FPR1 0.2
Publications: 7 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding GNAI3 0.425
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA14 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.404
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding FPR1 0.734
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation FPR1 0.8
Publications: 1 Organism: Homo Sapiens