Summary

Name KITLG
Full Name Kit ligand
Synonyms Mast cell growth factor, MGF, Stem cell factor, SCF, c-Kit ligand | MGF, SCF
Primary ID P21583
Links - -
Type protein
Relations 3
Pathways Malignant Melanoma, Acute Myeloid Leukemia, Mast cell: SCF
Function Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding KIT 0.86
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Mast cell: SCF, Malignant Melanoma
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KITLG 0.15
Publications: 1 Organism: Homo Sapiens