| + |
PRKCA | down-regulates activity 
phosphorylation
|
TBXA2R (isoform 2) |
0.493 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274092 |
Ser145 |
FSRPAVAsQRRAWAT |
Homo sapiens |
|
| pmid |
sentence |
| 16956790 |
These data suggest a model whereby agonist-induced PKC phosphorylation of Ser(145) partially impairs TPbeta signalling while GRK2/3 phosphorylation at both Ser(239) and Ser(357) within its IC(3) and C-tail domains, respectively, sterically inhibits G-protein coupling, profoundly desensitizing signalling, and promotes beta-arrestin association and, in turn, facilitates TPbeta internalization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GRK2 | down-regulates activity
phosphorylation
|
TBXA2R (isoform 2) |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274088 |
Ser239 |
AQQRPRDsEVEMMAQ |
Homo sapiens |
|
| pmid |
sentence |
| 16956790 |
These data suggest a model whereby agonist-induced PKC phosphorylation of Ser(145) partially impairs TPbeta signalling while GRK2/3 phosphorylation at both Ser(239) and Ser(357) within its IC(3) and C-tail domains, respectively, sterically inhibits G-protein coupling, profoundly desensitizing signalling, and promotes beta-arrestin association and, in turn, facilitates TPbeta internalization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274089 |
Ser357 |
RLPGSSDsRASASRA |
Homo sapiens |
|
| pmid |
sentence |
| 16956790 |
These data suggest a model whereby agonist-induced PKC phosphorylation of Ser(145) partially impairs TPbeta signalling while GRK2/3 phosphorylation at both Ser(239) and Ser(357) within its IC(3) and C-tail domains, respectively, sterically inhibits G-protein coupling, profoundly desensitizing signalling, and promotes beta-arrestin association and, in turn, facilitates TPbeta internalization. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
GRK3 | down-regulates activity
phosphorylation
|
TBXA2R (isoform 2) |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274090 |
Ser239 |
AQQRPRDsEVEMMAQ |
Homo sapiens |
|
| pmid |
sentence |
| 16956790 |
These data suggest a model whereby agonist-induced PKC phosphorylation of Ser(145) partially impairs TPbeta signalling while GRK2/3 phosphorylation at both Ser(239) and Ser(357) within its IC(3) and C-tail domains, respectively, sterically inhibits G-protein coupling, profoundly desensitizing signalling, and promotes beta-arrestin association and, in turn, facilitates TPbeta internalization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274091 |
Ser357 |
RLPGSSDsRASASRA |
Homo sapiens |
|
| pmid |
sentence |
| 16956790 |
These data suggest a model whereby agonist-induced PKC phosphorylation of Ser(145) partially impairs TPbeta signalling while GRK2/3 phosphorylation at both Ser(239) and Ser(357) within its IC(3) and C-tail domains, respectively, sterically inhibits G-protein coupling, profoundly desensitizing signalling, and promotes beta-arrestin association and, in turn, facilitates TPbeta internalization. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
3.0
TBXA2R
- 
- 