3.0
Summary
| Name |  UBA1View Modifications |
| Full Name | Ubiquitin-like modifier-activating enzyme 1 |
| Synonyms | Protein A1S9, Ubiquitin-activating enzyme E1 | A1S9T, UBE1 |
| Primary ID | P22314 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Pathways | Ubiquitin activation |
| Function | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CDK1 | up-regulates 
phosphorylation
|
UBA1 | 0.414 |
| Publications: | 3 | Organism: | Homo Sapiens | |
| + | UBA1 | form complex 
binding
|
Ub:E1 (UBA1 substrate) | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Ubiquitin activation | |||