Relation Results

Summary

Name FPR2
Full Name N-formyl peptide receptor 2
Synonyms FMLP-related receptor I, FMLP-R-I, Formyl peptide receptor-like 1, HM63, Lipoxin A4 receptor, LXA4 receptor, RFP | FPRH1, FPRL1, LXA4R
Primary ID P25090
Links - -
Type protein
Relations 5
Function Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the rece ...
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Type: Score: Layout: SPV 
0.80.4270.5390.6410.427WKYMVmFPR2GNA14CAMPANXA1GNAI3

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Relations
Regulator
Mechanism
target
score ℹ
+ WKYMVmup-regulates activity img/direct-activation.png chemical activation FPR2 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-257493 Homo sapiens
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ FPR2up-regulates activity img/direct-activation.png binding GNA14 0.427
Identifier Residue Sequence Organism Cell Line
SIGNOR-256888 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ CAMPup-regulates img/direct-activation.png binding FPR2 0.539
Identifier Residue Sequence Organism Cell Line
SIGNOR-82701 Homo sapiens T-lymphocyte, Monocyte
pmid sentence
Ll-37 may contribute to innate and adaptive immunity by recruiting neutrophils, monocytes, and t cells to sites of microbial invasion by interacting with fprl1.
Publications: 1 Organism: Homo Sapiens
+ ANXA1up-regulates activity img/direct-activation.png binding FPR2 0.641
Identifier Residue Sequence Organism Cell Line
SIGNOR-259437 Homo sapiens HEK-293 Cell
pmid sentence
We show that the mimetic N-terminal annexin 1 peptide Ac1-25 is able to activate and desensitize not only FPR but also FPRL1 and FPRL2.
Publications: 1 Organism: Homo Sapiens
+ FPR2up-regulates activity img/direct-activation.png binding GNAI3 0.427
Identifier Residue Sequence Organism Cell Line
SIGNOR-256745 Homo sapiens
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
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