| + |
MARK3 | up-regulates activity 
phosphorylation
|
ARHGEF2 |
0.392 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277368 |
Ser151 |
LSLAKSVsTTNIAGH |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 29089450 |
Rho-Rac guanine nucleotide exchange factor 2 (ARHGEF2), which activates Ras homolog family member A (RHOA), is anchored to the microtubule network and sequestered in an inhibited state through binding to dynein light chain Tctex-1 type 1 (DYNLT1). We showed in mammalian cells that liver kinase B1 (LKB1) activated the microtubule affinity-regulating kinase 3 (MARK3), which in turn phosphorylated ARHGEF2 at Ser151 This modification disrupted the interaction between ARHGEF2 and DYNLT1 by generating a 14-3-3 binding site in ARHGEF2, thus causing ARHGEF2 to dissociate from microtubules. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STK11 | up-regulates activity
phosphorylation
|
MARK3 |
0.32 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104059 |
Ser215 |
KLDTFCGsPPYAAPE |
Homo sapiens |
HeLa-S3 Cell |
| pmid |
sentence |
| 12879020 |
Regulation of the wnt signalling component par1a by the peutz-jeghers syndrome kinase lkb1. Lkb1 is a master kinase that activates 13 kinases of the ampk subfamily, including mark/par-1. Mark3 is activated by phosphorylation on thr-211. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104063 |
Thr211 |
TVGGKLDtFCGSPPY |
Homo sapiens |
HeLa-S3 Cell |
| pmid |
sentence |
| 12879020 |
Regulation of the wnt signalling component par1a by the peutz-jeghers syndrome kinase lkb1. Lkb1 is a master kinase that activates 13 kinases of the ampk subfamily, including mark/par-1. Mark3 is activated by phosphorylation on thr-211. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MARK3 | down-regulates activity 
phosphorylation
|
CDC25C |
0.499 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250176 |
Ser216 |
SGLYRSPsMPENLNR |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 9543386 |
C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. Phosphorylation of serine 21 6 promotes 1 4-3-3 binding to Cdc25C and is inhibitory to Cdc25C function. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
MARK3 | down-regulates activity
phosphorylation
|
TNK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273868 |
Ser502 |
RMKGISRsLESVLSL |
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 34504101 |
We also discover a MARK-mediated phosphorylation on TNK1 at S502 that promotes an interaction between TNK1 and 14-3-3, which sequesters TNK1 and inhibits its kinase activity.Phosphorylation of TNK1 at S502 within the proline rich domain is required for TNK1 binding to 14-3-3.MARKs mediate phosphorylation at S502 and 14-3-3 binding to TNK1, which restrains the movement of TNK1 into heavy membrane-associated clusters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIM1 | down-regulates
phosphorylation
|
MARK3 |
0.427 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-128260 |
Ser96 |
KTQLNPTsLQKLFRE |
Homo sapiens |
|
| pmid |
sentence |
| 15319445 |
Here we show that the protein kinase cdc25 c-associated kinase 1 (c-tak1) is a binding partner and a substrate of pim-1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-128264 |
Thr90 |
AIKIIDKtQLNPTSL |
Homo sapiens |
|
| pmid |
sentence |
| 15319445 |
Here we show that the protein kinase cdc25 c-associated kinase 1 (c-tak1) is a binding partner and a substrate of pim-1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-128268 |
Thr95 |
DKTQLNPtSLQKLFR |
Homo sapiens |
|
| pmid |
sentence |
| 15319445 |
Here we show that the protein kinase cdc25 c-associated kinase 1 (c-tak1) is a binding partner and a substrate of pim-1. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
PIM | down-regulates
phosphorylation
|
MARK3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259432 |
Ser96 |
KTQLNPTsLQKLFRE |
Homo sapiens |
|
| pmid |
sentence |
| 15319445 |
Here we show that the protein kinase cdc25 c-associated kinase 1 (c-tak1) is a binding partner and a substrate of pim-1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259431 |
Thr90 |
AIKIIDKtQLNPTSL |
Homo sapiens |
|
| pmid |
sentence |
| 15319445 |
Here we show that the protein kinase cdc25 c-associated kinase 1 (c-tak1) is a binding partner and a substrate of pim-1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259430 |
Thr95 |
DKTQLNPtSLQKLFR |
Homo sapiens |
|
| pmid |
sentence |
| 15319445 |
Here we show that the protein kinase cdc25 c-associated kinase 1 (c-tak1) is a binding partner and a substrate of pim-1. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
PRKCZ | down-regulates
phosphorylation
|
MARK3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124221 |
Thr564 |
RGTASRStFHGQPRE |
Homo sapiens |
|
| pmid |
sentence |
| 15084291 |
Hpar-1a, t564, is phosphorylated in vivo and by apkc in vitro.This study establishes a novel functional link between two central determinants of cellular polarity, apkc and par-1, and suggests a model by which apkc may regulate par-1 in polarized cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MARK3
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