Relation Results

Summary

Name MAP4
Full Name Microtubule-associated protein 4
Synonyms MAP-4
Primary ID P27816
Links - -
Type protein
Relations 12
Function Non-neuronal microtubule-associated protein. Promotes microtubule assembly.

Viewer

Type: Score: Layout: SPV 
0.4440.5070.20.20.7MARK1MAP4CDK1TTKCHEK1Microtubule_polimerization

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ MARK1down-regulates activity img/direct_inhibition.png phosphorylation MAP4 0.444
Identifier Residue Sequence Organism Cell Line
SIGNOR-250169 Ser1073 KAQAKVGsLDNVGHL in vitro
pmid sentence
Here we show that p110mark phosphorylates analogous KXGS sites in the microtubule binding domains of the neuronal MAP2 and the ubiquitous MAP4. Phosphorylation in vitro leads to the dissociation of MAP2 and MAP4 from microtubules and to a pronounced increase in dynamic instability.
Identifier Residue Sequence Organism Cell Line
SIGNOR-250170 Ser928 SRLATNTsAPDLKNV in vitro
pmid sentence
Here we show that p110mark phosphorylates analogous KXGS sites in the microtubule binding domains of the neuronal MAP2 and the ubiquitous MAP4. Phosphorylation in vitro leads to the dissociation of MAP2 and MAP4 from microtubules and to a pronounced increase in dynamic instability.
Identifier Residue Sequence Organism Cell Line
SIGNOR-250171 Ser941 NVRSKVGsTENIKHQ in vitro
pmid sentence
Here we show that p110mark phosphorylates analogous KXGS sites in the microtubule binding domains of the neuronal MAP2 and the ubiquitous MAP4. Phosphorylation in vitro leads to the dissociation of MAP2 and MAP4 from microtubules and to a pronounced increase in dynamic instability.
Publications: 3 Organism: In Vitro
+ CDK1down-regulates img/direct_inhibition.png phosphorylation MAP4 0.507
Identifier Residue Sequence Organism Cell Line
SIGNOR-53735 Ser696 PNKELPPsPEKKTKP Homo sapiens HeLa Cell
pmid sentence
Map4 is phosphorylated by cdc2 kinase in mitotic hela/ phosphorylation by cdc2 kinase decreased the microtubule-stabilizing ability of map4, suggesting that there are critical phosphorylation sites among the five major cdc2 kinase-dependent phosphorylation sites [spots 4 (ser-696), 5, 6, 9, and 10 (ser-787)].
Identifier Residue Sequence Organism Cell Line
SIGNOR-77087 Ser787 KAPEKRAsPSKPASA Homo sapiens
pmid sentence
Ser787 in the proline-rich region of human map4 is a critical phosphorylation site that reduces its activity to promote tubulin polymerization. Phosphorylation on ser-787 negatively regulates map4 activity to promote microtubule assembly.
Identifier Residue Sequence Organism Cell Line
SIGNOR-53739 Ser787 KAPEKRAsPSKPASA Homo sapiens HeLa Cell
pmid sentence
Map4 is phosphorylated by cdc2 kinase in mitotic hela/ phosphorylation by cdc2 kinase decreased the microtubule-stabilizing ability of map4, suggesting that there are critical phosphorylation sites among the five major cdc2 kinase-dependent phosphorylation sites [spots 4 (ser-696), 5, 6, 9, and 10 (ser-787)].
Publications: 3 Organism: Homo Sapiens
+ CDK1 img/unknown.png phosphorylation MAP4 0.507
Identifier Residue Sequence Organism Cell Line
SIGNOR-277461 Ser696 PNKELPPsPEKKTKP Homo sapiens HeLa Cell
pmid sentence
We have shown that MAP4 is phosphorylated in vivo in mitotic HeLa cells at eight sites. Five of these were phosphorylated by p34cdc2 kinase. Two of the five p34cdc2 kinase phosphorylation sites were shown to be Ser696 and Ser787 in the proline-rich region
Publications: 1 Organism: Homo Sapiens
+ CDK1down-regulates activity img/direct_inhibition.png phosphorylation MAP4 0.507
Identifier Residue Sequence Organism Cell Line
SIGNOR-277459 Ser787 KAPEKRAsPSKPASA Homo sapiens HeLa Cell
pmid sentence
We have shown that MAP4 is phosphorylated in vivo in mitotic HeLa cells at eight sites. Five of these were phosphorylated by p34cdc2 kinase. Two of the five p34cdc2 kinase phosphorylation sites were shown to be Ser696 and Ser787 in the proline-rich region. Mutation of Ser787 to Glu strikingly reduced the MAP4's MT-polymerization activity, while Glu-mutation at Ser696 did not. These results suggest that Ser787 could be the critical phosphorylation site causing MTs to be dynamic at mitosis.
Publications: 1 Organism: Homo Sapiens
+ TTKdown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation MAP4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277458 Ser928 SRLATNTsAPDLKNV Homo sapiens HeLa Cell
pmid sentence
We further uncovered that Mps1 is a kinase of MAP4, and E7-MAP4 binding blocks Mps1 phosphorylation of MAP4, thereby interrupting phosphorylation-dependent MAP4 degradation. 
Identifier Residue Sequence Organism Cell Line
SIGNOR-277462 Thr927 LSRLATNtSAPDLKN Homo sapiens HeLa Cell
pmid sentence
We further uncovered that Mps1 is a kinase of MAP4, and E7-MAP4 binding blocks Mps1 phosphorylation of MAP4, thereby interrupting phosphorylation-dependent MAP4 degradation. 
Publications: 2 Organism: Homo Sapiens
+ CHEK1down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation MAP4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277846 Thr521 MALGKDVtPPPETEV Homo sapiens
pmid sentence
MAP4 is a novel target of FBXW7 via the phosphorylated threonine T521 modified by CHEK1 in ESCC. The threonine T521 of MAP4, which was phosphorylated by CHEK1, played a key role in the FBXW7-related degradation system.
Publications: 1 Organism: Homo Sapiens
+ MAP4up-regulates img/indirect-activation.png Microtubule_polimerization 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-277460 Homo sapiens
pmid sentence
We have shown that MAP4 is phosphorylated in vivo in mitotic HeLa cells at eight sites. Five of these were phosphorylated by p34cdc2 kinase. Two of the five p34cdc2 kinase phosphorylation sites were shown to be Ser696 and Ser787 in the proline-rich region. Mutation of Ser787 to Glu strikingly reduced the MAP4's MT-polymerization activity, while Glu-mutation at Ser696 did not. These results suggest that Ser787 could be the critical phosphorylation site causing MTs to be dynamic at mitosis.
Publications: 1 Organism: Homo Sapiens
a simple tooltip