4.0
Summary
| Name |  RRM2View Modifications |
| Full Name | Ribonucleoside-diphosphate reductase subunit M2 |
| Synonyms | Ribonucleotide reductase small chain, Ribonucleotide reductase small subunit | RR2 |
| Primary ID | P31350 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Inhibitors | clofarabine; hydroxyurea; (2R,3S,4S,5R)-2-(6-amino-2-fluoro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol; gemcitabine |
| Function | Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CDK1 |
phosphorylation
|
RRM2 | 0.506 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK1 | down-regulates 
phosphorylation
|
RRM2 | 0.506 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | YAP1 | up-regulates quantity by expression 
transcriptional regulation
|
RRM2 | 0.2 |
| Publications: | 1 | |||
| Tissue: | MCF-10A Cell | |||
| + | clofarabine | down-regulates activity
chemical inhibition
|
RRM2 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | hydroxyurea | down-regulates activity
chemical inhibition
|
RRM2 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RRM2 | form complex 
binding
|
Ribonucleotide reductase | 0.933 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | (2R,3S,4S,5R)-2-(6-amino-2-fluoro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol | down-regulates activity
chemical inhibition
|
RRM2 | 0.8 |
| Publications: | 1 | Organism: | In Vitro | |
| + | YAP/TAZ | up-regulates quantity by expression
transcriptional regulation
|
RRM2 | 0.2 |
| Publications: | 1 | |||
| + | gemcitabine | down-regulates activity
chemical inhibition
|
RRM2 | 0.8 |
| Publications: | 1 | Organism: | In Vitro | |