Summary
Name | RRM2 View Modifications |
Full Name | Ribonucleoside-diphosphate reductase subunit M2 |
Synonyms | Ribonucleotide reductase small chain, Ribonucleotide reductase small subunit | RR2 |
Primary ID | P31350 |
Links | - - |
Type | protein |
Relations | 7 |
Inhibitors | (2R,3S,4S,5R)-2-(6-amino-2-fluoro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol; clofarabine; hydroxyurea; gemcitabine |
Function | Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. |
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Modifications Tables
Relations
Regulator | Mechanism | target | score ℹ | |
---|---|---|---|---|
+ | CDK1 | phosphorylation | RRM2 | 0.522 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | CDK1 | down-regulates phosphorylation | RRM2 | 0.522 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | RRM2 | form complex binding | Ribonucleotide reductase | 0.931 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | (2R,3S,4S,5R)-2-(6-amino-2-fluoro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol | down-regulates activity chemical inhibition | RRM2 | 0.8 |
Publications: | 1 | Organism: | In Vitro | |
+ | clofarabine | down-regulates activity chemical inhibition | RRM2 | 0.8 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | hydroxyurea | down-regulates activity chemical inhibition | RRM2 | 0.8 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | gemcitabine | down-regulates activity chemical inhibition | RRM2 | 0.8 |
Publications: | 1 | Organism: | In Vitro | |