| + |
IL2 | up-regulates 
binding
|
IL2RG |
0.865 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144543 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16477002 |
Il-2 is a cytokine that functions as a growth factor and central regulator in the immune system and mediates its effects through ligand-induced hetero-trimerization of the receptor subunits il-2r alpha, il-2r beta, and gamma(c). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL4R | up-regulates
binding
|
IL2RG |
0.829 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100765 |
|
|
Homo sapiens |
T-lymphocyte, Macrophage, Monocyte |
| pmid |
sentence |
| 12704343 |
The type i il-4 receptors result from association of IL-4R With the common ? Chain (?c), which is also a component of the receptors for il-2, il-7, il-9, and il-15. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-37362 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8266078 |
Il-2r gamma was demonstrated to be a component of the il-4 receptor on the basis of chemical cross-linking data, the ability of il-2r gamma to augment il-4 binding affinity, and the requirement for il-2r gamma in il-4-mediated phosphorylation of insulin receptor substrate-1. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Lung, Smooth Muscle |
| + |
IL9 | up-regulates
binding
|
IL2RG |
0.579 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-108867 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11418623 |
The common gamma-chain (gamma(c)) is an indispensable subunit of the functional receptor complexes for il-4, il-7, il-9, and il-15 as well as il-2. Here we show that the gamma(c) is also shared with the il-21r complex |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL15 | up-regulates
binding
|
IL2RG |
0.852 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-108815 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11418623 |
The common gamma-chain (gamma(c)) is an indispensable subunit of the functional receptor complexes for il-4, il-7, il-9, and il-15 as well as il-2. Here we show that the gamma(c) is also shared with the il-21r complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL4 | up-regulates
binding
|
IL2RG |
0.857 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-108861 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11418623 |
The common gamma-chain (gamma(c)) is an indispensable subunit of the functional receptor complexes for il-4, il-7, il-9, and il-15 as well as il-2. Here we show that the gamma(c) is also shared with the il-21r complex |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
125-L-serine-2-133-interleukin 2 (human reduced) | up-regulates activity
chemical activation
|
IL2RG |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259390 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18031103 |
Aldesleukin (recombinant IL-2) has similar pharmacodynamic properties to endogenous IL-2 and, when administered to patients with cancer, stimulates the antitumour immune response. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL21 | up-regulates
binding
|
IL2RG |
0.607 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-108858 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11418623 |
The common gamma-chain (gamma(c)) is an indispensable subunit of the functional receptor complexes for il-4, il-7, il-9, and il-15 as well as il-2. Here we show that the gamma(c) is also shared with the il-21r complex |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL7 | up-regulates
binding
|
IL2RG |
0.709 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163545 |
|
|
Homo sapiens |
Satellite Cell |
| pmid |
sentence |
| 20089933 |
This receptor (il-7r) is a heterodimer consisting of the il-7r chain and the common cytokine ? -chain. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-108864 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11418623 |
The common gamma-chain (gamma(c)) is an indispensable subunit of the functional receptor complexes for il-4, il-7, il-9, il-15, il-2, il21 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle, Myotube |
| + |
IL2RG | up-regulates
binding
|
JAK3 |
0.745 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178491 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 18445337 |
Jak3 is associated with the ?c20,21. Cytokine binding mediates the trans-phosphorylation of receptor associated jak kinases, which in turn phosphorylate tyrosine residues on the receptors themselves. The receptor phosphotyrosines serve as docking sites for sh2 domain proteins including the stat family of transcription factors which are activated by jak-mediated phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
denileukin diftitox | up-regulates activity
chemical activation
|
IL2RG |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259394 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15757436 |
Denileukin diftitox (DAB389IL-2; Ontak) is a novel recombinant fusion protein approved by the US Food and Drug Administration for the treatment of relapsed or refractory cutaneous T-cell lymphoma. It consists of fragments of diphtheria toxin linked to human interleukin-2 and works by targeting the high-affinity interleukin-2 receptor expressed on malignant cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
IL2RG
- 
- 