4.0
Summary
| Name |  SFNView Modifications |
| Full Name | 14-3-3 protein sigma |
| Synonyms | Epithelial cell marker protein 1, Stratifin | HME1 |
| Primary ID | P31947 |
| Links |  -  -  |
| Type | protein |
| Relations | 8 |
| Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAPK9 | down-regulates 
phosphorylation
|
SFN | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK10 | down-regulates
phosphorylation
|
SFN | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK8 | down-regulates
phosphorylation
|
SFN | 0.339 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SFN | down-regulates activity
relocalization
|
YAP1 | 0.46 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SFN | down-regulates
relocalization
|
SNAI1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRIM25 | down-regulates quantity by destabilization
ubiquitination
|
SFN | 0.571 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | JNK | down-regulates
phosphorylation
|
SFN | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | verteporfin | up-regulates quantity 
chemical activation
|
SFN | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |