Summary

Name ABCC1
Full Name Multidrug resistance-associated protein 1
Synonyms ATP-binding cassette sub-family C member 1, Leukotriene C(4) transporter, LTC4 transporter | MRP, MRP1
Primary ID P33527
Links - -
Type protein
Relations 2
Function Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation ABCC1 0.13
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABCC1 0.08
Publications: 1 Organism: Homo Sapiens