Summary

Name ABCC1
Full Name Multidrug resistance-associated protein 1
Synonyms ATP-binding cassette sub-family C member 1, Leukotriene C(4) transporter, LTC4 transporter | MRP, MRP1
Primary ID P33527
Links - -
Type protein
Relations 5
Inhibitors doxorubicin; daunorubicin
Function Mediates export of organic anions and drugs from the cytoplasm (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation ABCC1 0.381
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition ABCC1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABCC1 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation ABCC1 0.8
Publications: 1 Organism: Mesocricetus Auratus
+ down-regulates activity img/direct_inhibition.png chemical inhibition ABCC1 0.8
Publications: 1 Organism: Homo Sapiens