4.0
Summary
| Name |  CTNNA1View Modifications |
| Full Name | Catenin alpha-1 |
| Synonyms | Alpha E-catenin, Cadherin-associated protein, Renal carcinoma antigen NY-REN-13 |
| Primary ID | P35221 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Pathways | Hippo Signaling, YAP/TAZ regulation |
| Function | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK2A1 | down-regulates 
phosphorylation
|
CTNNA1 | 0.39 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTPN11 | down-regulates
dephosphorylation
|
CTNNA1 | 0.434 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDH11 |
binding
|
CTNNA1 | 0.488 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CTNNA1 | down-regulates
binding
|
YAP1 | 0.353 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Hippo Signaling | |||
| + | CDH1 | up-regulates 
binding
|
CTNNA1 | 0.685 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Hippo Signaling | |||