Summary

Name SCN4A
Full Name Sodium channel protein type 4 subunit alpha
Synonyms SkM1, Sodium channel protein skeletal muscle subunit alpha, Sodium channel protein type IV subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.4 |
Primary ID P35499
Links - -
Type protein
Relations 10
Function Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Alternates between resting, activated and inactivated states (PubMed:12766226, PubMed:29992740, PubMed:30190309, PubMed:15318338, PubMed:16890191, PubMed:18690054, PubMed:17898326, PubMed:19347921, PubMed:25707578, PubMed:26700687). Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles, and constant muscle strength in the presence of fluctuating K(+) levels (PubMed:12766226, PubMed:15318338, PubMed:16890191, PubMed:19347921, PubMed:25707578, PubMed:26700687, PubMed:26659129).

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Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png binding SCN4A 0.256
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ down-regulates activity img/direct_inhibition.png binding SCN4A 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates img/indirect-activation.png Action_potential 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN4A 0.2
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png binding SCN4A 0.265
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ down-regulates activity img/direct_inhibition.png binding SCN4A 0.259
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png SCN4A 0.262
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SCN4A 0.262
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity img/direct-activation.png relocalization sodium(1+) 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination SCN4A 0.285
Publications: 1 Organism: Mus Musculus