Summary

Name SOAT1
Full Name Sterol O-acyltransferase 1
Synonyms Acyl-coenzyme A:cholesterol acyltransferase 1, ACAT-1, Cholesterol acyltransferase 1 | ACACT, ACACT1, ACAT, ACAT1, SOAT, STAT
Primary ID P35610
Links - -
Type protein
Relations 3
Inhibitors Avasimibe
Function Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:16154994, PubMed:16647063, PubMed:9020103, PubMed:32433614, PubMed:32433613). Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:16154994, PubMed:9020103). Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) preferentially as susbstrate

Viewer

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png chemical inhibition SOAT1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png chemical modification cholesteryl ester 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation SOAT1 0.8
Publications: 1 Organism: Homo Sapiens
Tissue: Liver