Summary

Name DDIT3
Full Name DNA damage-inducible transcript 3 protein
Synonyms DDIT-3, C/EBP zeta, C/EBP-homologous protein, CHOP, C/EBP-homologous protein 10, CHOP-10, CCAAT/enhancer-binding protein homologous protein, Growth arrest and DNA damage-inducible protein GADD153 | CHOP, CHOP10, GADD153
Primary ID P35638
Links - -
Type protein
Relations 21
Pathways COVID-19 Causal Network, P38 Signaling, SARS-CoV MAPK PERTURBATION, SARS-CoV ER STRESS
Function Multifunctional transcription factor in endoplasmic reticulum (ER) stress response (PubMed:15322075, PubMed:15775988, PubMed:19672300). Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress (PubMed:15322075, PubMed:15775988). Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes (By similarity). Acts as a dominant-negative regulator of C/EBP-induced transcription

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation DDIT3 0.351
Publications: 4 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ down-regulates activity img/direct_inhibition.png phosphorylation DDIT3 0.268
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation DDIT3 0.593
Publications: 2 Organism: Homo Sapiens, In Vitro
Pathways:P38 Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TRIB3 0.591
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation DDIT3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation DDIT3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Apoptosis 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, P38 Signaling, SARS-CoV MAPK PERTURBATION, SARS-CoV ER STRESS
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation CEBPB 0.668
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation DDIT3 0.2
Publications: 1 Organism: In Vitro
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation CEBPA 0.534
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PPP1R15A 0.467
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ER STRESS
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation DDIT3 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ER STRESS
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation DDIT3 0.809
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ER STRESS
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation DDIT3 0.645
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ER STRESS
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ANKRD1 0.277
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation DDIT3 0.596
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ASNS 0.381
Publications: 1 Organism: Homo Sapiens