| + |
SRC | down-regulates 
phosphorylation
|
CHRNA7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141307 |
Tyr386 |
ASNGNLLyIGFRGLD |
Homo sapiens |
|
| pmid |
sentence |
| 16251431 |
?7 Neuronal nicotinic acetylcholine receptors are negatively regulated by tyrosine phosphorylation and src-family kinases |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141311 |
Tyr442 |
KILEEVRyIANRFRC |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 16251431 |
Alpha7 neuronal nicotinic acetylcholine receptors are negatively regulated by tyrosine phosphorylation and src-family kinasesmutant alpha7 nachrs lacking cytoplasmic loop tyrosine residues because of alanine replacement of tyr-386 and tyr-442 were more active than wild-type receptorsexpression of active src reduced _7 nachr activity |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CHRNA7 | up-regulates activity 
binding
|
RHOA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253985 |
|
|
|
|
| pmid |
sentence |
| 27167578 |
Here, we demonstrate a role for α7 nAChR/G protein interaction in the activation of the small (monomeric) RhoA GTPase leading to cytoskeletal changes during neurite growth. Treatment of PC12 cells with the α7 nAChR agonist choline or PNU-282987 was associated with an increase in RhoA activity and an inhibition in neurite growth. |
|
| Publications: |
1 |
| + |
acetylcholine | up-regulates activity
chemical activation
|
CHRNA7 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253984 |
|
|
|
|
| pmid |
sentence |
| 27167578 |
Here, we demonstrate a role for α7 nAChR/G protein interaction in the activation of the small (monomeric) RhoA GTPase leading to cytoskeletal changes during neurite growth. Treatment of PC12 cells with the α7 nAChR agonist choline or PNU-282987 was associated with an increase in RhoA activity and an inhibition in neurite growth. |
|
| Publications: |
1 |
3.0
CHRNA7
- 
- 