| + |
PBX1 | down-regulates quantity by repression 
transcriptional regulation
|
FGF8 |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265803 |
|
|
Mus musculus |
CCE Cell |
| pmid |
sentence |
| 10026229 |
Our results in ES cells suggest that Engrailed inhibits Fgf8 expression in the absence of Pbx1. We identified single Engrailed- and Pbx-binding sites in the Fgf8 intron that inhibit expression of Fgf8 in mouse ES cells, but that together can allow full Fgf8 expression. Our data support the model that Engrailed heterodimerized with Pbx might activate transcription, while Engrailed or Pbx proteins alone might repress transcription |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265777 |
|
|
Mus musculus |
CCE Cell |
| pmid |
sentence |
| 10026229 |
Our results in ES cells suggest that Engrailed inhibits Fgf8 expression in the absence of Pbx1. We identified single Engrailed- and Pbx-binding sites in the Fgf8 intron that inhibit expression of Fgf8 in mouse ES cells, but that together can allow full Fgf8 expression. Our data support the model that Engrailed heterodimerized with Pbx might activate transcription, while Engrailed or Pbx proteins alone might repress transcription |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
PBX1 | up-regulates quantity by expression 
transcriptional regulation
|
CDKN2A |
0.317 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267239 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 21746878 |
We show that the Pbx1 and Meis2 homeodomain proteins interact with Klf4 and can be recruited to DNA elements comprising a Klf4 site or G C box, with adjacent Meis and Pbx sites. Meis2d and Pbx1a activate expression of p15(Ink4a) and E-cadherin, dependent on the Meis2d transcriptional activation domain. We suggest a model in which genes with Klf4 sites can be cooperatively activated by Meis2/Pbx1 and Klf4, dependent primarily on recruitment by Klf4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZNF462 | down-regulates activity
binding
|
PBX1 |
0.316 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264477 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 17353115 |
We demonstrated that ZFPIP is expressed in embryonic female genital tract but also in other PBX1 expression domains such as the developing head and the limb buds. We further showed that ZFPIP is able to bind physically and in vivo to PBX1 and moreover, that it prevents the binding of HOXA9/PBX complexes to their consensus DNA site. We suggest that ZFPIP is a new type of PBX1 partner that could participate in PBX1 function during several developmental pathways. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
PBX1 | form complex 
binding
|
MYOD1/SWI/SNF complex |
0.422 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151700 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17194702 |
Myod targets brg1 to the myogenin promoter during the initiation of myogenesis in tissue culture models for skeletal muscle differentiation /initiation of myogenin transcription is dependent upon myod, the pbx homeodomain factor, and swi/snf chromatin-remodeling enzymes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
PKNOX1 | up-regulates activity
binding
|
PBX1 |
0.729 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241212 |
|
|
in vitro |
|
| pmid |
sentence |
| 9482740 |
we show that Pbx proteins exist as stable heterodimers with a novel homeodomain protein, Prep1. Here we show that Prep1-Pbx interaction presents novel structural features: it is independent of DNA binding and of the integrity of their respective homeodomains, and requires sequences in the N-terminal portions of both proteins. The Prep1-Pbx protein-protein interaction is essential for DNA-binding activity. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PBX1 | up-regulates quantity by expression
transcriptional regulation
|
CDH1 |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267241 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 21746878 |
We show that the Pbx1 and Meis2 homeodomain proteins interact with Klf4 and can be recruited to DNA elements comprising a Klf4 site or G C box, with adjacent Meis and Pbx sites. Meis2d and Pbx1a activate expression of p15(Ink4a) and E-cadherin, dependent on the Meis2d transcriptional activation domain. We suggest a model in which genes with Klf4 sites can be cooperatively activated by Meis2/Pbx1 and Klf4, dependent primarily on recruitment by Klf4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOXB8 | up-regulates activity
binding
|
PBX1 |
0.516 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-223153 |
|
|
Homo sapiens |
Acute Myeloid Leukemia Cell |
| pmid |
sentence |
| 11571641 |
the ability of HoxB8 to heterodimerizes with endogenous Pbx proteins on DNA alters gene transcription in a manner that prevents progression through an intrinsic genetic differentiation program. In conjunction with Pbx, HoxB8 could alter transcription of Pbx target genes by direct or indirect mechanisms. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MECOM | up-regulates quantity by expression 
transcriptional regulation
|
PBX1 |
0.441 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188155 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 19767769 |
In this study, we identified pbx1, a proto-oncogene in hematopoietic malignancy, as a target gene of evi-1. Overexpression of evi-1 increased pbx1 expression in hematopoietic stem/progenitor cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PBX1 | up-regulates activity
binding
|
HOXB1 |
0.796 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241219 |
|
|
in vitro |
|
| pmid |
sentence |
| 10052460 |
Pbx1 and exd act as cofactors that enhance the DNA binding specificity of Hox proteins. The structure of the HoxB1Pbx1DNA ternary complex shows that HoxB1 and Pbx1 bind to overlapping binding sites located on opposite faces of the DNA. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
KLF4 | up-regulates activity
binding
|
PBX1 |
0.453 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267237 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 21746878 |
We show that the Pbx1 and Meis2 homeodomain proteins interact with Klf4 and can be recruited to DNA elements comprising a Klf4 site or G C box, with adjacent Meis and Pbx sites. Meis2d and Pbx1a activate expression of p15(Ink4a) and E-cadherin, dependent on the Meis2d transcriptional activation domain. We suggest a model in which genes with Klf4 sites can be cooperatively activated by Meis2/Pbx1 and Klf4, dependent primarily on recruitment by Klf4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PBX1 | up-regulates activity
binding
|
MYOD1 |
0.422 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124834 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15149596 |
These domains are necessary for the stable binding of myod to the myogenin promoter through an interaction with an adjacent protein complex containing the homeodomain protein pbx, which appears to be constitutively bound at this site |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
PBXIP1 | down-regulates activity
binding
|
PBX1 |
0.342 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273666 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24488098 |
This protein that we have termed hematopoietic PBX-interacting protein (HPIP) is mainly localized in the cytosol and in small amounts in the nucleus. The region of PBX that interacts with HPIP includes both the homeodomain and immediate N-terminal flanking sequences. Strikingly, electrophoretic mobility shift assays revealed that HPIP inhibits the ability of PBX-HOX heterodimers to bind to target sequences. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PBX1
- 
- 