| + |
TRAF6 | up-regulates quantity by stabilization 
ubiquitination
|
KLF4 |
0.286 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277464 |
Lys32 |
SGPAGREkTLRQAGA |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 31281496 |
We further found that inhibition of polo-like kinase 1 could downregulate the expression of KLF4 and that PLK1 directly phosphorylated KLF4 at Ser234. Notably, phosphorylation of KLF4 by PLK1 caused the recruitment and binding of the E3 ligase TRAF6, which resulted in KLF4 K32 K63-linked ubiquitination and stabilization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLK1 | up-regulates quantity by stabilization
phosphorylation
|
KLF4 |
0.25 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277463 |
Ser234 |
GKFVLKAsLSAPGSE |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 31281496 |
We further found that inhibition of polo-like kinase 1 could downregulate the expression of KLF4 and that PLK1 directly phosphorylated KLF4 at Ser234. Notably, phosphorylation of KLF4 by PLK1 caused the recruitment and binding of the E3 ligase TRAF6, which resulted in KLF4 K32 K63-linked ubiquitination and stabilization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT6 | up-regulates quantity by expression 
transcriptional regulation
|
KLF4 |
0.348 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254519 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25934862 |
IL-4-induced macrophage polarization involves induction of STAT6 and KLF4 that induce each other and promote M2 polarization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLF4 | down-regulates quantity by repression 
transcriptional regulation
|
TNF |
0.334 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254520 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 22378047 |
KLF4 cooperates with Stat6 to induce M2 genes (Arg-1, Mrc1, Fizz1, PPARγ) and inhibit M1 genes (TNFa, Cox-2, CCL5, iNOS) via sequestration of coactivators required for NF-κB activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLF4 | down-regulates quantity by repression 
transcriptional regulation
|
TP53 |
0.564 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270544 |
|
|
|
|
| pmid |
sentence |
| 17308127 |
Previous work has shown that the Kruppel-like factor 4 (KLF4) transcription factor represses p53 transcription by binding to the PE21 element. |
|
| Publications: |
1 |
| + |
Cullin 1-RBX1-Skp1 | down-regulates quantity by destabilization
ubiquitination
|
KLF4 |
0.374 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273445 |
|
|
Homo sapiens |
Liver Cancer Cell |
| pmid |
sentence |
| 26087183 |
F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLF4 | down-regulates
binding
|
SRF |
0.371 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174258 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21673106 |
Klf4 antagonizes contractile gene expression through diverse mechanisms including (i) inhibiting the binding of srf-myocd or srf-mrtfs to the carg box by direct association with srf. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Smooth Muscle |
| + |
KLF4 | up-regulates quantity by expression
transcriptional regulation
|
HSPA8 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254544 |
|
|
Mus musculus |
C2C12 Cell, RAW-264.7 Cell |
| pmid |
sentence |
| 18379898 |
The results showed the upregulation of the HSP73 constitutive expression by KLF4 overexpression in both C2C12 cells and murine RAW264.7 macrophages; in response to heat stress, however, few changes were observed in the levels of HSP73 by KLF4 overexpression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
KLF4 | up-regulates quantity by expression
transcriptional regulation
|
NPNT |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255457 |
|
|
Homo sapiens |
Skeletal Muscle Satellite Cell |
| pmid |
sentence |
| 23612709 |
The MEK5-dependent activation of ERK5 promotes binding of the transcription factor SP1 to the promoter of the genes encoding the transcription factors Klf2 and Klf4, leading to their increased abundance. Subsequently, Klf2 and Klf4 bind to the Npnt promoter and induce the production of nephronectin during myoblast fusion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
CTNNB1 | up-regulates activity
binding
|
KLF4 |
0.685 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242100 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24482235 |
The interaction of Beta-catenin with Tcf is important for Beta-catenin s's function in iPSCs induction. In addition, Beta-catenin interacts with Oct4, Sox2, and Klf4, respectively. In the reprogramming process, Beta-catenin further enhances expression of pluripotency-related genes. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MAPK7 | up-regulates quantity by expression
transcriptional regulation
|
KLF4 |
0.433 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255455 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23612709 |
The MEK5-dependent activation of ERK5 promotes binding of the transcription factor SP1 to the promoter of the genes encoding the transcription factors Klf2 and Klf4, leading to their increased abundance. Subsequently, Klf2 and Klf4 bind to the Npnt promoter and induce the production of nephronectin during myoblast fusion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HUWE1 | down-regulates quantity by destabilization
ubiquitination
|
KLF4 |
0.34 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278749 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28084302 |
K48 linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression.|Instead, we identified the transcription factor KLF4 as a novel Mule substrate that is ubiquitinated by this E3 ligase and thus undergoes proteasomal degradation in T cells.|Here we report that Lys-48-linked ubiquitination of the transcription factor KLF4 mediated by the E3 ligase Mule promotes T-cell entry into S phase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT6 | up-regulates quantity by expression
transcriptional regulation
|
KLF4 |
0.348 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249568 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22378047 |
STAT6 coordinates and synergizes with both PPAR? and Krppel-like factor 4 (KLF4), a member of a family of proteins that contribute to macrophage function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLF4 | up-regulates activity
binding
|
MEIS2 |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267238 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21746878 |
We show that the Pbx1 and Meis2 homeodomain proteins interact with Klf4 and can be recruited to DNA elements comprising a Klf4 site or G C box, with adjacent Meis and Pbx sites. Meis2d and Pbx1a activate expression of p15(Ink4a) and E-cadherin, dependent on the Meis2d transcriptional activation domain. We suggest a model in which genes with Klf4 sites can be cooperatively activated by Meis2/Pbx1 and Klf4, dependent primarily on recruitment by Klf4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLF4 | down-regulates
|
MYOCD |
0.469 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174255 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21673106 |
Finally, we demonstrate that the basal expression of both myocd and mrtf-a is negatively regulated by klf4. . The mechanism of inhibition of myocd or mrtf-a by klf4 is currently unclear and warrants future study. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Smooth Muscle |
| + |
KLF4 | up-regulates activity
transcriptional regulation
|
THBD |
0.304 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254546 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19661484 |
Thrombomodulin upregulation was independent of NF-kappaB signaling, a principal target of proteasome inhibitors, but was instead a direct consequence of increased expression of the Krüppel-like transcription factors, KLF2 and KLF4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLF4 | up-regulates activity
binding
|
PBX1 |
0.476 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267237 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 21746878 |
We show that the Pbx1 and Meis2 homeodomain proteins interact with Klf4 and can be recruited to DNA elements comprising a Klf4 site or G C box, with adjacent Meis and Pbx sites. Meis2d and Pbx1a activate expression of p15(Ink4a) and E-cadherin, dependent on the Meis2d transcriptional activation domain. We suggest a model in which genes with Klf4 sites can be cooperatively activated by Meis2/Pbx1 and Klf4, dependent primarily on recruitment by Klf4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXO22 | down-regulates quantity by destabilization
ubiquitination
|
KLF4 |
0.366 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273444 |
|
|
Homo sapiens |
Liver Cancer Cell |
| pmid |
sentence |
| 26087183 |
F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MUC1 | up-regulates activity
binding
|
KLF4 |
0.282 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270543 |
|
|
|
|
| pmid |
sentence |
| 17308127 |
Previous work has shown that the Kruppel-like factor 4 (KLF4) transcription factor represses p53 transcription by binding to the PE21 element. Our results show that MUC1-C binds constitutively to KLF4, occupies PE21 with KLF4, and enhances the KLF4 occupancy of PE21. |
|
| Publications: |
1 |
| + |
KLF4 | down-regulates quantity by repression
transcriptional regulation
|
SOD1 |
0.292 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254545 |
|
|
Homo sapiens |
BE(2)-M17 Cell |
| pmid |
sentence |
| 23370975 |
The expression of superoxide dismutase (SOD) 1 in both mRNA and protein levels was found to be decreased by overexpressing KLF4, while increased by knockdown of KLF4 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MRTFA | down-regulates
|
KLF4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174261 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21673106 |
This result suggests that mrtf-a, but not myocd, is essential for bmp4-dependent induction ofmir-143/145gene transcription. Of the mirnas identified to target klf4, only mir-143 and mir-145 were induced at least 1.5-fold by both bmp4 and tgf- , suggesting that they may be critical for bmp4- and tgf- -mediated reduction of klf4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLF4 | up-regulates
|
STAT6 |
0.348 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249569 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 22378047 |
KLF4 cooperates with Stat6 to induce M2 genes (Arg-1, Mrc1, Fizz1, PPAR?) and inhibit M1 genes (TNFa, Cox-2, CCL5, iNOS) via sequestration of coactivators required for NF-kappaB activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYOCD | down-regulates
|
KLF4 |
0.469 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174319 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21673106 |
These results further confirm that bmp4 requires mrtf-a, whereas tgf-_ requires myocd for the induction of pri-mir-143/145 and down-regulation of klf4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
KLF4
- 
- 