| + |
CSNK2A2 | up-regulates activity 
phosphorylation
|
PPP1R2 |
0.311 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251020 |
Ser121 |
YRIQEQEsSGEEDSD |
in vitro |
|
| pmid |
sentence |
| 8288648 |
Recombinant wild-type I-2 and the Ala-120/121 mutant were phosphorylated synergistically by GSK-3 and casein kinase II. The Thr-72 and Ser-86 mutants, however, did not undergo this synergistic phosphorylation. Our studies indicate that Thr-72 is the only GSK-3 site and that Ser-86 is the casein kinase II site required for the potentiation of GSK-3 action. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251021 |
Ser122 |
RIQEQESsGEEDSDL |
in vitro |
|
| pmid |
sentence |
| 8288648 |
Recombinant wild-type I-2 and the Ala-120/121 mutant were phosphorylated synergistically by GSK-3 and casein kinase II. The Thr-72 and Ser-86 mutants, however, did not undergo this synergistic phosphorylation. Our studies indicate that Thr-72 is the only GSK-3 site and that Ser-86 is the casein kinase II site required for the potentiation of GSK-3 action. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251022 |
Ser87 |
GDDEDACsDTEATEA |
in vitro |
|
| pmid |
sentence |
| 8288648 |
Recombinant wild-type I-2 and the Ala-120/121 mutant were phosphorylated synergistically by GSK-3 and casein kinase II. The Thr-72 and Ser-86 mutants, however, did not undergo this synergistic phosphorylation. Our studies indicate that Thr-72 is the only GSK-3 site and that Ser-86 is the casein kinase II site required for the potentiation of GSK-3 action. |
|
| Publications: |
3 |
Organism: |
In Vitro |
| + |
CSNK2A1 | up-regulates
phosphorylation
|
PPP1R2 |
0.311 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53857 |
Ser121 |
YRIQEQEsSGEEDSD |
Homo sapiens |
|
| pmid |
sentence |
| 9405437 |
Recombinant inh2 was phosphorylated by kinases in cytosols prepared from g1 and s phase cells. The amount of inh2 kinase attributed to casein kinase 2, based on inhibition by heparin, increased 2.6-fold from g1 to s phase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53861 |
Ser122 |
RIQEQESsGEEDSDL |
Homo sapiens |
|
| pmid |
sentence |
| 9405437 |
Recombinant inh2 was phosphorylated by kinases in cytosols prepared from g1 and s phase cells. The amount of inh2 kinase attributed to casein kinase 2, based on inhibition by heparin, increased 2.6-fold from g1 to s phase |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ATM | down-regulates 
phosphorylation
|
PPP1R2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160648 |
Ser44 |
DEELSKKsQKWDEMN |
Homo sapiens |
|
| pmid |
sentence |
| 18250156 |
Atm phosphorylates i-2 on serine 43, leading to the dissociation of the pp1-i-2 complex and the activation of pp1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSNK2A1 | up-regulates activity
phosphorylation
|
PPP1R2 |
0.311 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250929 |
Ser87 |
GDDEDACsDTEATEA |
in vitro |
|
| pmid |
sentence |
| 8288648 |
Recombinant wild-type I-2 and the Ala-120/121 mutant were phosphorylated synergistically by GSK-3 and casein kinase II. The Thr-72 and Ser-86 mutants, however, did not undergo this synergistic phosphorylation. Our studies indicate that Thr-72 is the only GSK-3 site and that Ser-86 is the casein kinase II site required for the potentiation of GSK-3 action. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
GSK3B | up-regulates activity
phosphorylation
|
PPP1R2 |
0.422 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251257 |
Thr73 |
MKIDEPStPYHSMMG |
Bos taurus |
Brain |
| pmid |
sentence |
| 11320080 |
Protein phosphatase 1 (PP1) is complexed with inhibitor 2 (I-2) in the cytosol. In rabbit muscle extract PP1.I-2 is activated upon preincubation with ATP/Mg. This activation is caused by phosphorylation of I-2 on Thr(72) by glycogen synthase kinase 3 (GSK3). |
|
| Publications: |
1 |
Organism: |
Bos Taurus |
| + |
CDK5 |
phosphorylation
|
PPP1R2 |
0.363 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250672 |
Thr73 |
MKIDEPStPYHSMMG |
in vitro |
|
| pmid |
sentence |
| 11320080 |
Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2. | NCLK Phosphorylates Thr72 of I-2 |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PPP1R2 | down-regulates
binding
|
PP1 |
0.808 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264672 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18250156 |
Atm phosphorylates i-2 on serine 43, leading to the dissociation of the pp1-i-2 complex and the activation of pp1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP1R2 | down-regulates
binding
|
PPP1CA |
0.791 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160651 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18250156 |
Atm phosphorylates i-2 on serine 43, leading to the dissociation of the pp1-i-2 complex and the activation of pp1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PPP1R2
- 
- 