| + |
CDK5 | up-regulates 
phosphorylation
|
HTT |
0.46 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156836 |
Ser1179 |
LTNPPSLsPIRRKGK |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 17611284 |
Huntingtin is an antiapoptotic proteinwe show here that huntingtin is phosphorylated by the cyclin-dependent kinase 5 (cdk5) at serines 1181 and 1201. Phosphorylation can be induced by dna damage in vitro and in vivo. The state of huntingtin phosphorylation is a crucial regulator of neuronal cell death. Absence of phosphorylation of huntingtin at serines 1181 and 1201 confers toxic properties to wild-type huntingtin in a p53-dependent manner in striatal neurons and accelerates neuronal death induced by dna damage. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156840 |
Ser1199 |
EQASVPLsPKKGSEA |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 17611284 |
Huntingtin is an antiapoptotic proteinwe show here that huntingtin is phosphorylated by the cyclin-dependent kinase 5 (cdk5) at serines 1181 and 1201. Phosphorylation can be induced by dna damage in vitro and in vivo. The state of huntingtin phosphorylation is a crucial regulator of neuronal cell death. Absence of phosphorylation of huntingtin at serines 1181 and 1201 confers toxic properties to wild-type huntingtin in a p53-dependent manner in striatal neurons and accelerates neuronal death induced by dna damage. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
TBK1 | up-regulates activity
phosphorylation
|
HTT |
0.294 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270350 |
Ser13 |
KLMKAFEsLKSFQQQ |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 32757223 |
Herein, we report the discovery and validation of a kinase, TANK-binding kinase 1 (TBK1), that efficiently phosphorylates full-length and N-terminal HTT fragments in vitro (at S13/S16), in cells (at S13) and in vivo. TBK1 expression in HD models (cells, primary neurons, and Caenorhabditis elegans) increases mutant HTT exon 1 phosphorylation and reduces its aggregation and cytotoxicity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKACA | down-regulates quantity by destabilization 
phosphorylation
|
HTT |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277625 |
Ser2548 |
TRFGRKLsIIRGIVE |
in vitro |
|
| pmid |
sentence |
| 35908190 |
Moreover, phosphorylation of C-HEAT Ser2550 by cAMP-dependent protein kinase (PKA), the top hit in kinase activity screens, was found to hasten huntingtin degradation, such that levels of the catalytic subunit (PRKACA) were inversely related to huntingtin levels. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
SGK1 | down-regulates
phosphorylation
|
HTT |
0.381 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-121349 |
Ser419 |
GGRSRSGsIVELIAG |
Homo sapiens |
|
| pmid |
sentence |
| 14725621 |
The serum- and glucocorticoid-induced kinase sgk inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT |
phosphorylation
|
HTT |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-89696 |
Ser419 |
GGRSRSGsIVELIAG |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 12062094 |
We demonstrate that huntingtin is a substrate of akt and that phosphorylation of huntingtin by akt is crucial to mediate the neuroprotective effects of igf-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT1 |
phosphorylation
|
HTT |
0.569 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252590 |
Ser419 |
GGRSRSGsIVELIAG |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 12062094 |
We demonstrate that huntingtin is a substrate of akt and that phosphorylation of huntingtin by akt is crucial to mediate the neuroprotective effects of igf-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
HTT
- 
- 