Summary

Name MATR3
Full Name Matrin-3
Synonyms MATR3_HUMAN | KIAA0723
Primary ID P43243
Links - -
Type protein
Relations 1
Function May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). May bind to specific miRNA hairpins (PubMed:28431233).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png relocalization MATR3 0.507
Publications: 1 Organism: Homo Sapiens