| + |
CSNK2A1 | up-regulates 
phosphorylation
|
CBX5 |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-171695 |
Ser11 |
KTKRTADsSSSEDEE |
Homo sapiens |
|
| pmid |
sentence |
| 21245376 |
Hp1_ was multiply phosphorylated at n-terminal serine residues (s11-14) in human and mouse cells and that this phosphorylation enhanced hp1_'s affinity for h3k9me. Unphosphorylatable mutant hp1_ exhibited severe heterochromatin localization defects in vivo, and its prolonged expression led to increased chromosomal instability. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-171699 |
Ser12 |
TKRTADSsSSEDEEE |
Homo sapiens |
|
| pmid |
sentence |
| 21245376 |
Hp1_ was multiply phosphorylated at n-terminal serine residues (s11-14) in human and mouse cells and that this phosphorylation enhanced hp1_'s affinity for h3k9me. Unphosphorylatable mutant hp1_ exhibited severe heterochromatin localization defects in vivo, and its prolonged expression led to increased chromosomal instability. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-171703 |
Ser13 |
KRTADSSsSEDEEEY |
Homo sapiens |
|
| pmid |
sentence |
| 21245376 |
Hp1_ was multiply phosphorylated at n-terminal serine residues (s11-14) in human and mouse cells and that this phosphorylation enhanced hp1_'s affinity for h3k9me. Unphosphorylatable mutant hp1_ exhibited severe heterochromatin localization defects in vivo, and its prolonged expression led to increased chromosomal instability. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-171707 |
Ser14 |
RTADSSSsEDEEEYV |
Homo sapiens |
|
| pmid |
sentence |
| 21245376 |
Hp1_ was multiply phosphorylated at n-terminal serine residues (s11-14) in human and mouse cells and that this phosphorylation enhanced hp1_'s affinity for h3k9me. Unphosphorylatable mutant hp1_ exhibited severe heterochromatin localization defects in vivo, and its prolonged expression led to increased chromosomal instability. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
E2F5 | down-regulates quantity by repression 
transcriptional regulation
|
CBX5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261591 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 21374739 |
We identified for E2F5 a repressor function for HP1a expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ASXL3 | down-regulates activity
binding
|
CBX5 |
0.254 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266763 |
|
|
Homo sapiens |
HEP-3B Cell |
| pmid |
sentence |
| 25450400 |
Here, we showed that ASXL3 interacts with HP1α and LSD1, leading to transcriptional repression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POGZ | down-regulates activity
binding
|
CBX5 |
0.444 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264487 |
|
|
Homo sapiens |
Neuroblastoma Cell Line |
| pmid |
sentence |
| 20562864 |
POGZ was found to bind to HP1alpha through a zinc-finger-like motif. Binding by POGZ, mediated through its zinc-finger-like motif, competed with PxVxL proteins and destabilized the HP1alpha-chromatin interaction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CBX5 | up-regulates activity
binding
|
H3-3A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264488 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19111658 |
A core characteristic of heterochromatin is its association with heterochromatin protein 1 (HP1) proteins, a highly conserved family of chromosomal proteins that bind to di- and trimethylated H3K9 via a conserved N-terminal domain called the chromodomain (CD) HP1 proteins are a highly conserved family of eukaryotic proteins that bind to methylated histone H3 lysine 9 (H3K9) and are required for heterochromatic gene silencing. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Cullin 1-RBX1-Skp1 | down-regulates quantity by destabilization
polyubiquitination
|
CBX5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271934 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23431138 |
As expected, the SKP1 and CUL1 proteins, subunits of all F-box-containing E3 ligases, were also present in the immune complexes containing FBXO10 and BCL2. To test for FBXO10-induced ubiquitination of BCL2, 293T cells were transduced with retroviral vectors expressing Flag-tagged FBXO10, MYC-tagged BCL2, and HA-tagged ubiquitin, and cells were treated with the proteasome inhibitor PS-341 to enhance the detection of ubiquitinated proteins.Together, these data suggest that FBXO10 is a component of a ubiquitin ligase that can target BCL2 protein for degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CBX5 | up-regulates activity
binding
|
Histone H3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265325 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19111658 |
A core characteristic of heterochromatin is its association with heterochromatin protein 1 (HP1) proteins, a highly conserved family of chromosomal proteins that bind to di- and trimethylated H3K9 via a conserved N-terminal domain called the chromodomain (CD) HP1 proteins are a highly conserved family of eukaryotic proteins that bind to methylated histone H3 lysine 9 (H3K9) and are required for heterochromatic gene silencing. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CBX5 | up-regulates activity
binding
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264489 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19111658 |
A core characteristic of heterochromatin is its association with heterochromatin protein 1 (HP1) proteins, a highly conserved family of chromosomal proteins that bind to di- and trimethylated H3K9 via a conserved N-terminal domain called the chromodomain (CD) HP1 proteins are a highly conserved family of eukaryotic proteins that bind to methylated histone H3 lysine 9 (H3K9) and are required for heterochromatic gene silencing. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CBX5 | up-regulates activity
binding
|
H3C1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264490 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19111658 |
A core characteristic of heterochromatin is its association with heterochromatin protein 1 (HP1) proteins, a highly conserved family of chromosomal proteins that bind to di- and trimethylated H3K9 via a conserved N-terminal domain called the chromodomain (CD) HP1 proteins are a highly conserved family of eukaryotic proteins that bind to methylated histone H3 lysine 9 (H3K9) and are required for heterochromatic gene silencing. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNF123 | down-regulates quantity by destabilization
polyubiquitination
|
CBX5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272035 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23077635 |
In the present study, we report that HP1α and β undergo proteasomal degradation in lamin A/C knock-down cells and show by ectopic expression, RNAi and binding studies that the RING finger ubiquitin ligase RNF123 is directly involved in HP1 degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXW10 | down-regulates quantity by destabilization
binding
|
CBX5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271933 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23431138 |
As expected, the SKP1 and CUL1 proteins, subunits of all F-box-containing E3 ligases, were also present in the immune complexes containing FBXO10 and BCL2. To test for FBXO10-induced ubiquitination of BCL2, 293T cells were transduced with retroviral vectors expressing Flag-tagged FBXO10, MYC-tagged BCL2, and HA-tagged ubiquitin, and cells were treated with the proteasome inhibitor PS-341 to enhance the detection of ubiquitinated proteins.Together, these data suggest that FBXO10 is a component of a ubiquitin ligase that can target BCL2 protein for degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CBX5
- 
- 