Summary

Name FBXW10
Full Name F-box/WD repeat-containing protein 10
Synonyms F-box and WD-40 domain-containing protein 10, Ubiquitin ligase-specificity factor |
Primary ID Q5XX13
Links - -
Type protein
Relations 2
Function Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1. {ECO:0000269|PubMed:20498703}.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding Cullin 1-RBX1-Skp1 0.608
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding CBX5 0.2
Publications: 1 Organism: Homo Sapiens