Relation Results

Summary

Name USP5
Full Name Ubiquitin carboxyl-terminal hydrolase 5
Synonyms Deubiquitinating enzyme 5, Isopeptidase T, Ubiquitin thioesterase 5, Ubiquitin-specific-processing protease 5 | ISOT
Primary ID P45974
Links - -
Type protein
Relations 4
Pathways Ubiquitin activation
Function Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquit ...
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Type: Score: Layout: SPV 
0.8430.3550.8420.76USP5UbiquitinFOXM1UBCUBB

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Relations
Regulator
Mechanism
target
score ℹ
+ USP5up-regulates quantity img/direct-activation.png cleavage Ubiquitin 0.843
Identifier Residue Sequence Organism Cell Line
SIGNOR-270830 Homo sapiens HeLa Cell
pmid sentence
Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors.
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
+ USP5up-regulates quantity by stabilization img/direct-activation.png deubiquitination FOXM1 0.355
Identifier Residue Sequence Organism Cell Line
SIGNOR-277210 Homo sapiens HEK-293T Cell
pmid sentence
 Wnt signaling activation inhibits FoxM1 phosphorylation by GSK3-Axin complex and leads to interaction between FoxM1 and deubiquitinating enzyme USP5, thereby deubiquitination and stabilization of FoxM1.
Publications: 1 Organism: Homo Sapiens
+ USP5up-regulates quantity img/direct-activation.png cleavage UBC 0.842
Identifier Residue Sequence Organism Cell Line
SIGNOR-270822 Homo sapiens HeLa Cell
pmid sentence
Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors.
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
+ USP5up-regulates quantity img/direct-activation.png cleavage UBB 0.76
Identifier Residue Sequence Organism Cell Line
SIGNOR-270821 Homo sapiens HeLa Cell
pmid sentence
Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors.
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
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