| + |
ATP5PO | form complex
binding
|
ATP synthase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261403 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21874297 |
Human mitochondrial ATP synthase, or complex V, consists of two functional domains, F1 and Fo. F1 comprises 5 different subunits (three α, three β, and one γ, δ and ε) and is situated in the mitochondrial matrix. Fo contains subunits c, a, b, d, F6, OSCP and the accessory subunits e, f, g and A6L. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MTFP1 | up-regulates quantity by stabilization
binding
|
ATP5PO |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282568 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 41663153 |
We revealed MTFP1, a protein that plays an important role in cell viability and mitochondrial dynamics, as a driver of PDAC liver colonisation. Mechanistically, MTFP1 is recognised as a novel ATP synthase modulator through its interaction with numerous ATP synthase subunits, thereby enhancing oxidative phosphorylation (OXPHOS). Strikingly, MTFP1 OE had no significant impact on the stability of ATP5A1, ATP5B and ATP5O in total lysates (online supplemental figure S4J,K); however, it dramatically slowed the degradation of these subunits in the mitochondria (figure 4H–J, online supplemental figure S4L), suggesting that MTFP1 acted as an ATP synthase modulator. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPIF | up-regulates activity
binding
|
ATP5PO |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264881 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 32814770 |
We here hypothesized that CypD phosphorylation on its residue S191 induces its translocation and binding to the OSCP to favor mPTP opening. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |