| + |
MTFP1 | up-regulates quantity by stabilization 
binding
|
ATP synthase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282569 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 41663153 |
We revealed MTFP1, a protein that plays an important role in cell viability and mitochondrial dynamics, as a driver of PDAC liver colonisation. Mechanistically, MTFP1 is recognised as a novel ATP synthase modulator through its interaction with numerous ATP synthase subunits, thereby enhancing oxidative phosphorylation (OXPHOS). Strikingly, MTFP1 OE had no significant impact on the stability of ATP5A1, ATP5B and ATP5O in total lysates (online supplemental figure S4J,K); however, it dramatically slowed the degradation of these subunits in the mitochondria (figure 4H–J, online supplemental figure S4L), suggesting that MTFP1 acted as an ATP synthase modulator. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP5F1D | form complex 
binding
|
ATP synthase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261402 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21874297 |
Human mitochondrial ATP synthase, or complex V, consists of two functional domains, F1 and Fo. F1 comprises 5 different subunits (three α, three β, and one γ, δ and ε) and is situated in the mitochondrial matrix. Fo contains subunits c, a, b, d, F6, OSCP and the accessory subunits e, f, g and A6L. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP5MC1 | form complex
binding
|
ATP synthase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261409 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21874297 |
Human mitochondrial ATP synthase, or complex V, consists of two functional domains, F1 and Fo. F1 comprises 5 different subunits (three α, three β, and one γ, δ and ε) and is situated in the mitochondrial matrix. Fo contains subunits c, a, b, d, F6, OSCP and the accessory subunits e, f, g and A6L. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261399 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21874297 |
Human mitochondrial ATP synthase, or complex V, consists of two functional domains, F1 and Fo. F1 comprises 5 different subunits (three α, three β, and one γ, δ and ε) and is situated in the mitochondrial matrix. Fo contains subunits c, a, b, d, F6, OSCP and the accessory subunits e, f, g and A6L. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ATP5PD | form complex
binding
|
ATP synthase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261404 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21874297 |
Human mitochondrial ATP synthase, or complex V, consists of two functional domains, F1 and Fo. F1 comprises 5 different subunits (three α, three β, and one γ, δ and ε) and is situated in the mitochondrial matrix. Fo contains subunits c, a, b, d, F6, OSCP and the accessory subunits e, f, g and A6L. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MT-ATP8 | form complex
binding
|
ATP synthase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261406 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21874297 |
Human mitochondrial ATP synthase, or complex V, consists of two functional domains, F1 and Fo. F1 comprises 5 different subunits (three α, three β, and one γ, δ and ε) and is situated in the mitochondrial matrix. Fo contains subunits c, a, b, d, F6, OSCP and the accessory subunits e, f, g and A6L. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP synthase | up-regulates quantity
chemical modification
|
ATP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261410 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21874297 |
Human mitochondrial (mt) ATP synthase, or complex V consists of two functional domains: F(1), situated in the mitochondrial matrix, and F(o), located in the inner mitochondrial membrane. Complex V uses the energy created by the proton electrochemical gradient to phosphorylate ADP to ATP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
ATP5IF1 | form complex
binding
|
ATP synthase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261400 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21874297 |
Human mitochondrial ATP synthase, or complex V, consists of two functional domains, F1 and Fo. F1 comprises 5 different subunits (three α, three β, and one γ, δ and ε) and is situated in the mitochondrial matrix. Fo contains subunits c, a, b, d, F6, OSCP and the accessory subunits e, f, g and A6L. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP5F1B | form complex
binding
|
ATP synthase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261397 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21874297 |
Human mitochondrial ATP synthase, or complex V, consists of two functional domains, F1 and Fo. F1 comprises 5 different subunits (three α, three β, and one γ, δ and ε) and is situated in the mitochondrial matrix. Fo contains subunits c, a, b, d, F6, OSCP and the accessory subunits e, f, g and A6L. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP5PB | form complex
binding
|
ATP synthase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261401 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21874297 |
Human mitochondrial ATP synthase, or complex V, consists of two functional domains, F1 and Fo. F1 comprises 5 different subunits (three α, three β, and one γ, δ and ε) and is situated in the mitochondrial matrix. Fo contains subunits c, a, b, d, F6, OSCP and the accessory subunits e, f, g and A6L. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP5PO | form complex
binding
|
ATP synthase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261403 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21874297 |
Human mitochondrial ATP synthase, or complex V, consists of two functional domains, F1 and Fo. F1 comprises 5 different subunits (three α, three β, and one γ, δ and ε) and is situated in the mitochondrial matrix. Fo contains subunits c, a, b, d, F6, OSCP and the accessory subunits e, f, g and A6L. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP5ME | form complex
binding
|
ATP synthase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261407 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21874297 |
Human mitochondrial ATP synthase, or complex V, consists of two functional domains, F1 and Fo. F1 comprises 5 different subunits (three α, three β, and one γ, δ and ε) and is situated in the mitochondrial matrix. Fo contains subunits c, a, b, d, F6, OSCP and the accessory subunits e, f, g and A6L. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATG4B | down-regulates activity 
|
ATP synthase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275837 |
|
|
Homo sapiens |
Colonic Cancer Cell |
| pmid |
sentence |
| 29165041 |
In this study, we identified a novel phosphorylation site at Ser34 of ATG4B induced by AKT in HCC cells.| In brief, our results demonstrate for the first time that the phosphorylation of ATG4B at Ser34 participates in the metabolic reprogramming of HCC cells via repressing mitochondrial function, which possibly results from the Ser34 phosphorylation-induced mitochondrial enrichment of ATG4B and the subsequent inhibition of F1Fo-ATP synthase activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP5MG | form complex
binding
|
ATP synthase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261408 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21874297 |
Human mitochondrial ATP synthase, or complex V, consists of two functional domains, F1 and Fo. F1 comprises 5 different subunits (three α, three β, and one γ, δ and ε) and is situated in the mitochondrial matrix. Fo contains subunits c, a, b, d, F6, OSCP and the accessory subunits e, f, g and A6L. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP5PF | form complex
binding
|
ATP synthase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261398 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21874297 |
Human mitochondrial ATP synthase, or complex V, consists of two functional domains, F1 and Fo. F1 comprises 5 different subunits (three α, three β, and one γ, δ and ε) and is situated in the mitochondrial matrix. Fo contains subunits c, a, b, d, F6, OSCP and the accessory subunits e, f, g and A6L. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP5F1C | form complex
binding
|
ATP synthase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261405 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21874297 |
Human mitochondrial ATP synthase, or complex V, consists of two functional domains, F1 and Fo. F1 comprises 5 different subunits (three α, three β, and one γ, δ and ε) and is situated in the mitochondrial matrix. Fo contains subunits c, a, b, d, F6, OSCP and the accessory subunits e, f, g and A6L. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hydron | up-regulates activity
chemical modification
|
ATP synthase |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280303 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31115493 |
The mammalian mitochondrial electron transport chain (ETC) includes complexes I‑IV, as well as the electron transporters ubiquinone and cytochrome c. There are two electron transport pathways in the ETC: Complex I/III/IV, with NADH as the substrate and complex II/III/IV, with succinic acid as the substrate. The electron flow is coupled with the generation of a proton gradient across the inner membrane and the energy accumulated in the proton gradient is used by complex V (ATP synthase) to produce ATP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP5F1A | form complex
binding
|
ATP synthase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261396 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21874297 |
Human mitochondrial ATP synthase, or complex V, consists of two functional domains, F1 and Fo. F1 comprises 5 different subunits (three α, three β, and one γ, δ and ε) and is situated in the mitochondrial matrix. Fo contains subunits c, a, b, d, F6, OSCP and the accessory subunits e, f, g and A6L. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
ATP synthase
CPX-6151