3.0
Summary
| Name |  PIP4K2AView Modifications |
| Full Name | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha |
| Synonyms | 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha, Diphosphoinositide kinase 2-alpha, PIP5KIII, Phosphatidylinositol 5-phosphate 4-kinase type II alpha, PI(5)P 4-kinase type II alpha, PIP4KII-alpha, PtdIns(4)P-5-kinase B isoform, PtdIns(4)P-5-kinase C isoform, PtdIns(5)P-4-kinase isoform 2-alpha | PIP5K2, PIP5K2A |
| Primary ID | P48426 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:9367159, PubMed:23326584). Has both ATP- and GTP-dependent kinase activities (PubMed:26774281). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 (PubMed:18364242). May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (By similarity). Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level (PubMed:29353240). In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress (By similarity). Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (PubMed:31091439). May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity). Negatively regulates insulin signaling through a catalytic-independent mechanism (PubMed:31091439). PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK2A1 | up-regulates 
phosphorylation
|
PIP4K2A | 0.43 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKD1 | down-regulates 
phosphorylation
|
PIP4K2A | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PIP4K2A | down-regulates quantity
chemical modification
|
1-phosphatidyl-1D-myo-inositol 5-phosphate(3-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ARF6 | up-regulates activity
|
PIP4K2A | 0.344 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | PIP4K2A | up-regulates quantity
chemical modification
|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |