| + |
ARF6 | up-regulates activity 
|
PIP4K2A |
0.345 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264911 |
|
|
Rattus norvegicus |
Pyramidal Neuron |
| pmid |
sentence |
| 14565977 |
Effects of ARF6 upon Axonogenesis Are Mediated by Phosphatidyl-inositol-4-phosphate 5-Kinase α. activated ARF6 stimulates the lipid-modifying enzyme PI(4)P 5-Kinase, leading to local increases in plasma membrane PIP2 and changes in actin dynamics. Alternatively, activation of Rac1 by upstream Rac1 activators or indirectly by ARF6-GTP results in stimulation of actin polymerization. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
ARF6 | up-regulates 
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264908 |
|
|
Rattus norvegicus |
Pyramidal Neuron |
| pmid |
sentence |
| 14565977 |
ARNO and ARF6 regulate axonal elongation and branching through downstream activation of phosphatidylinositol 4-phosphate 5-kinase alpha |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
Cullin 1-RBX1-Skp1 | down-regulates quantity by destabilization 
|
ARF6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271766 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 18094045 |
Fbx8 Is a Component of the SCF Complex and Mediates Ubiquitination of Arf6. We first examined whether Fbx8 makes a complex with Cul1, through its binding to Skp1. We expressed GST-tagged Fbx8 together with FLAG-tagged Skp1 and Myc-tagged Cul1 in Cos-7 cells and found that Myc-Cul1 is coprecipitated with GST-Fbx8 in the presence of FLAG-Skp1 (Figure 1A). |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
USP6 | up-regulates
relocalization
|
ARF6 |
0.645 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-130019 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15509780 |
Here we show that tre17 (also called tre-2 and usp6), a founding member of the tbc family, targets the arf family gtpase arf6, which regulates plasma membrane-endosome trafficking. Surprisingly, tre17 does not function as a gap for arf6 but rather promotes its activation in vivo. Forced expression of tre17 promotes the localization of arf6 to the plasma membrane, leading to arf6 activation, presumably due to facilitated access to membrane-associated guanine nucleotide exchange factors (gefs). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXO8 | down-regulates quantity by destabilization
binding
|
ARF6 |
0.699 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271764 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 18094045 |
Fbx8 Is a Component of the SCF Complex and Mediates Ubiquitination of Arf6. We first examined whether Fbx8 makes a complex with Cul1, through its binding to Skp1. We expressed GST-tagged Fbx8 together with FLAG-tagged Skp1 and Myc-tagged Cul1 in Cos-7 cells and found that Myc-Cul1 is coprecipitated with GST-Fbx8 in the presence of FLAG-Skp1 (Figure 1A). |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
ARF6 | up-regulates
|
Endocytosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272154 |
|
|
|
|
| pmid |
sentence |
| 14973189 |
ADP-ribosylation factors (ARF) are 20-kDa GTPases of the ras superfamily that regulate vesicular transport in eukaryotic cells. There are three classes of ARFs: class I (ARF1–3), which function in endoplasmic reticulum-Golgi trafficking; the much less studied class II (ARF4–5); and class III (ARF6), with significant roles in endocytotic pathways and cytoskeletal dynamics near the cell surface |
|
| Publications: |
1 |
| + |
ARF6 | up-regulates
|
Vesicle_transport |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272153 |
|
|
|
|
| pmid |
sentence |
| 14973189 |
ADP-ribosylation factors (ARF) are 20-kDa GTPases of the ras superfamily that regulate vesicular transport in eukaryotic cells. There are three classes of ARFs: class I (ARF1–3), which function in endoplasmic reticulum-Golgi trafficking; the much less studied class II (ARF4–5); and class III (ARF6), with significant roles in endocytotic pathways and cytoskeletal dynamics near the cell surface |
|
| Publications: |
1 |
| + |
ASAP2 | up-regulates activity
gtpase-activating protein
|
ARF6 |
0.654 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269706 |
|
|
in vitro |
|
| pmid |
sentence |
| 10022920 |
Pap is a multidomain protein composed of an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal SH3 domain. In addition, in vitro recombinant Pap exhibits strong GTPase-activating protein (GAP) activity towards the small GTPases Arf1 and Arf5 and weak activity towards Arf6. Pap protein exhibits Arf GAP activity in vitro. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
IQSEC2 | up-regulates activity
guanine nucleotide exchange factor
|
ARF6 |
0.471 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264906 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18164504 |
Here, we characterized IQ-ArfGEF/BRAG1, a guanine nucleotide exchange factor (GEF) for Arf6, in the mouse brain. In vivo Arf pull down assay demonstrated that IQ-ArfGEF/BRAG1 activated Arf6 more potently than Arf1.IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6 that interacts with PSD-95 at postsynaptic density of excitatory synapses. Taken together, IQ-ArfGEF/BRAG1 forms a postsynaptic protein complex containing PSD-95 and NMDA receptors at excitatory synapses, where it may function as a GEF for Arf6. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
CYTH2 | up-regulates activity
guanine nucleotide exchange factor
|
ARF6 |
0.883 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264910 |
|
|
Rattus norvegicus |
Pyramidal Neuron |
| pmid |
sentence |
| 14565977 |
Effects of ARNO upon Axonogenesis Are Mediated by Downstream Activation of ARF6. ARNO/ARF6 signaling pathways that could modulate actin reorganization in the axonal growth cone. ARNO stimulates GTP exchange on ARF6, thereby increasing the amount of active ARF6. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
3.0
ARF6
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