| + |
MASP1 | up-regulates activity 
cleavage
|
C2 |
0.511 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263417 |
Arg243 |
KTKESLGrKIQIQRS |
Homo sapiens |
Plasma Cell |
| pmid |
sentence |
| 11907111 |
The MASPs in the preparations had proteolytic activities against C4, C2, and C3 in the fluid phase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263420 |
Ser20 |
LYPGLADsAPSCPQN |
Homo sapiens |
Plasma Cell |
| pmid |
sentence |
| 11907111 |
The MASPs in the preparations had proteolytic activities against C4, C2, and C3 in the fluid phase |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Complement Signaling |
| + |
MASP1 | up-regulates activity
cleavage
|
C4B |
0.662 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263423 |
Arg679 |
EKTTRKKrNVNFQKA |
in vitro |
|
| pmid |
sentence |
| 9087411 |
The classical complement activation pathway, like the MELinitiated pathway, involves the generation of a C3-converting complex, C4b2b, through enzymatic activation of C4 and C2. In the C1 complex (C1qr2s2), this specific protease activity is exhibited by C1s after activation of this enzyme by C1r. When C4 is activated, its reactive thiol ester is exposed and C4b binds covalently to nearby amino or hydroxyl groups. The C4-activating abilities of MASP-1 and MASP-2 were compared.|Activation of C4 by Ct sand MASP-2 on western blots. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263426 |
Arg756 |
KGQAGLQrALEILQE |
in vitro |
|
| pmid |
sentence |
| 9087411 |
The classical complement activation pathway, like the MELinitiated pathway, involves the generation of a C3-converting complex, C4b2b, through enzymatic activation of C4 and C2. In the C1 complex (C1qr2s2), this specific protease activity is exhibited by C1s after activation of this enzyme by C1r. When C4 is activated, its reactive thiol ester is exposed and C4b binds covalently to nearby amino or hydroxyl groups. The C4-activating abilities of MASP-1 and MASP-2 were compared.|Activation of C4 by Ct sand MASP-2 on western blots. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263429 |
Gly1446 |
TPLQLFEgRRNRRRR |
in vitro |
|
| pmid |
sentence |
| 9087411 |
The classical complement activation pathway, like the MELinitiated pathway, involves the generation of a C3-converting complex, C4b2b, through enzymatic activation of C4 and C2. In the C1 complex (C1qr2s2), this specific protease activity is exhibited by C1s after activation of this enzyme by C1r. When C4 is activated, its reactive thiol ester is exposed and C4b binds covalently to nearby amino or hydroxyl groups. The C4-activating abilities of MASP-1 and MASP-2 were compared.|Activation of C4 by Ct sand MASP-2 on western blots. |
|
| Publications: |
3 |
Organism: |
In Vitro |
| + |
MASP1 | up-regulates activity
cleavage
|
C4A |
0.59 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263432 |
Arg679 |
EKTTRKKrNVNFQKA |
in vitro |
|
| pmid |
sentence |
| 9087411 |
The classical complement activation pathway, like the MELinitiated pathway, involves the generation of a C3-converting complex, C4b2b, through enzymatic activation of C4 and C2. In the C1 complex (C1qr2s2), this specific protease activity is exhibited by C1s after activation of this enzyme by C1r. When C4 is activated, its reactive thiol ester is exposed and C4b binds covalently to nearby amino or hydroxyl groups. The C4-activating abilities of MASP-1 and MASP-2 were compared.|Activation of C4 by Ct sand MASP-2 on western blots. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263435 |
Arg756 |
KGQAGLQrALEILQE |
in vitro |
|
| pmid |
sentence |
| 9087411 |
The classical complement activation pathway, like the MELinitiated pathway, involves the generation of a C3-converting complex, C4b2b, through enzymatic activation of C4 and C2. In the C1 complex (C1qr2s2), this specific protease activity is exhibited by C1s after activation of this enzyme by C1r. When C4 is activated, its reactive thiol ester is exposed and C4b binds covalently to nearby amino or hydroxyl groups. The C4-activating abilities of MASP-1 and MASP-2 were compared.|Activation of C4 by Ct sand MASP-2 on western blots. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263438 |
Gly1446 |
TPLQLFEgRRNRRRR |
in vitro |
|
| pmid |
sentence |
| 9087411 |
The classical complement activation pathway, like the MELinitiated pathway, involves the generation of a C3-converting complex, C4b2b, through enzymatic activation of C4 and C2. In the C1 complex (C1qr2s2), this specific protease activity is exhibited by C1s after activation of this enzyme by C1r. When C4 is activated, its reactive thiol ester is exposed and C4b binds covalently to nearby amino or hydroxyl groups. The C4-activating abilities of MASP-1 and MASP-2 were compared.|Activation of C4 by Ct sand MASP-2 on western blots. |
|
| Publications: |
3 |
Organism: |
In Vitro |
| Pathways: | Complement Signaling |
| + |
MBL2 | up-regulates activity
binding
|
MASP1 |
0.742 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263414 |
|
|
Homo sapiens |
Plasma Cell |
| pmid |
sentence |
| 9087411 |
The results (Fig. 3A) show that the anti-MBL antibody, in addition to binding MBL captures both MASP-1 and MASP-2|Our results emphasize the similarity between complement activation through the MBL, or 'MBLectin' pathway of the innate immune system and the classical pathway of complement activation (Fig. 5). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Complement Signaling |
| + |
COLEC11 | up-regulates activity
binding
|
MASP1 |
0.608 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263409 |
|
|
in vitro |
|
| pmid |
sentence |
| 20956340 |
On the basis of the significant concentration of CL-11 in circulation and CL-11's interaction with various microorganisms and MASP-1 and/or MASP-3, it is conceivable that CL-11 plays a role in activation of the complement system and in the defense against invading microorganisms. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
FCN2 | up-regulates activity
binding
|
MASP1 |
0.781 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263411 |
|
|
Homo sapiens |
Plasma Cell |
| pmid |
sentence |
| 11907111 |
H-ficolin binds to PSA, a polysaccharide produced by Aerococcus viridans. C4 was activated by H-ficolin preparations bound to PSA which had been coated on ELISA plates. These results indicate that H-ficolin is a second ficolin which is associated with MASPs and sMAP, and which activates the lectin pathway|Proteolytic activation of complement components by H-ficolin-MASP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FCN3 | up-regulates activity
binding
|
MASP1 |
0.661 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263410 |
|
|
Homo sapiens |
Plasma Cell |
| pmid |
sentence |
| 11907111 |
H-ficolin binds to PSA, a polysaccharide produced by Aerococcus viridans. C4 was activated by H-ficolin preparations bound to PSA which had been coated on ELISA plates. These results indicate that H-ficolin is a second ficolin which is associated with MASPs and sMAP, and which activates the lectin pathway|Proteolytic activation of complement components by H-ficolin-MASP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MASP1
- 
- 