| + |
MASP2 | up-regulates activity 
cleavage
|
C4A |
0.793 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263431 |
Arg679 |
EKTTRKKrNVNFQKA |
in vitro |
|
| pmid |
sentence |
| 17204478 |
MASP-2 cleaves C4 releasing C4a and generating C4b, which attaches covalently to the pathogen surface upon exposure of its reactive thioester. C2 binds to C4b and is also cleaved by MASP-2 to form the C3 convertase (C4b2a). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263434 |
Arg756 |
KGQAGLQrALEILQE |
in vitro |
|
| pmid |
sentence |
| 17204478 |
MASP-2 cleaves C4 releasing C4a and generating C4b, which attaches covalently to the pathogen surface upon exposure of its reactive thioester. C2 binds to C4b and is also cleaved by MASP-2 to form the C3 convertase (C4b2a). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263437 |
Gly1446 |
TPLQLFEgRRNRRRR |
in vitro |
|
| pmid |
sentence |
| 17204478 |
MASP-2 cleaves C4 releasing C4a and generating C4b, which attaches covalently to the pathogen surface upon exposure of its reactive thioester. C2 binds to C4b and is also cleaved by MASP-2 to form the C3 convertase (C4b2a). |
|
| Publications: |
3 |
Organism: |
In Vitro |
| Pathways: | Complement Signaling |
| + |
Complement C1 complex | up-regulates activity
cleavage
|
C4A |
0.63 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263433 |
Arg679 |
EKTTRKKrNVNFQKA |
in vitro |
|
| pmid |
sentence |
| 9087411 |
The classical complement activation pathway, like the MELinitiated pathway, involves the generation of a C3-converting complex, C4b2b, through enzymatic activation of C4 and C2. In the C1 complex (C1qr2s2), this specific protease activity is exhibited by C1s after activation of this enzyme by C1r. When C4 is activated, its reactive thiol ester is exposed and C4b binds covalently to nearby amino or hydroxyl groups. The C4-activating abilities of MASP-1 and MASP-2 were compared.|Activation of C4 by Ct sand MASP-2 on western blots. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263436 |
Arg756 |
KGQAGLQrALEILQE |
in vitro |
|
| pmid |
sentence |
| 9087411 |
The classical complement activation pathway, like the MELinitiated pathway, involves the generation of a C3-converting complex, C4b2b, through enzymatic activation of C4 and C2. In the C1 complex (C1qr2s2), this specific protease activity is exhibited by C1s after activation of this enzyme by C1r. When C4 is activated, its reactive thiol ester is exposed and C4b binds covalently to nearby amino or hydroxyl groups. The C4-activating abilities of MASP-1 and MASP-2 were compared.|Activation of C4 by Ct sand MASP-2 on western blots. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263439 |
Gly1446 |
TPLQLFEgRRNRRRR |
in vitro |
|
| pmid |
sentence |
| 9087411 |
The classical complement activation pathway, like the MELinitiated pathway, involves the generation of a C3-converting complex, C4b2b, through enzymatic activation of C4 and C2. In the C1 complex (C1qr2s2), this specific protease activity is exhibited by C1s after activation of this enzyme by C1r. When C4 is activated, its reactive thiol ester is exposed and C4b binds covalently to nearby amino or hydroxyl groups. The C4-activating abilities of MASP-1 and MASP-2 were compared.|Activation of C4 by Ct sand MASP-2 on western blots. |
|
| Publications: |
3 |
Organism: |
In Vitro |
| Pathways: | Complement Signaling |
| + |
MASP1 | up-regulates activity
cleavage
|
C4A |
0.59 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263432 |
Arg679 |
EKTTRKKrNVNFQKA |
in vitro |
|
| pmid |
sentence |
| 9087411 |
The classical complement activation pathway, like the MELinitiated pathway, involves the generation of a C3-converting complex, C4b2b, through enzymatic activation of C4 and C2. In the C1 complex (C1qr2s2), this specific protease activity is exhibited by C1s after activation of this enzyme by C1r. When C4 is activated, its reactive thiol ester is exposed and C4b binds covalently to nearby amino or hydroxyl groups. The C4-activating abilities of MASP-1 and MASP-2 were compared.|Activation of C4 by Ct sand MASP-2 on western blots. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263435 |
Arg756 |
KGQAGLQrALEILQE |
in vitro |
|
| pmid |
sentence |
| 9087411 |
The classical complement activation pathway, like the MELinitiated pathway, involves the generation of a C3-converting complex, C4b2b, through enzymatic activation of C4 and C2. In the C1 complex (C1qr2s2), this specific protease activity is exhibited by C1s after activation of this enzyme by C1r. When C4 is activated, its reactive thiol ester is exposed and C4b binds covalently to nearby amino or hydroxyl groups. The C4-activating abilities of MASP-1 and MASP-2 were compared.|Activation of C4 by Ct sand MASP-2 on western blots. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263438 |
Gly1446 |
TPLQLFEgRRNRRRR |
in vitro |
|
| pmid |
sentence |
| 9087411 |
The classical complement activation pathway, like the MELinitiated pathway, involves the generation of a C3-converting complex, C4b2b, through enzymatic activation of C4 and C2. In the C1 complex (C1qr2s2), this specific protease activity is exhibited by C1s after activation of this enzyme by C1r. When C4 is activated, its reactive thiol ester is exposed and C4b binds covalently to nearby amino or hydroxyl groups. The C4-activating abilities of MASP-1 and MASP-2 were compared.|Activation of C4 by Ct sand MASP-2 on western blots. |
|
| Publications: |
3 |
Organism: |
In Vitro |
| Pathways: | Complement Signaling |
| + |
C4A | form complex 
binding
|
C3 convertase complex |
0.607 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263400 |
|
|
in vitro |
|
| pmid |
sentence |
| 17204478 |
However, following cleavage of C4, C2 binds tightly to C4b to form the C4b2 complex |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Complement Signaling |
3.0
C4A
- 
- 