Relation Results

Summary

Name RGS7
Full Name Regulator of G-protein signaling 7
Synonyms RGS7 |
Primary ID P49802
Links - -
Type protein
Relations 1
Function Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, t ...
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Type: Score: Layout: SPV 
0.365PRKCARGS7

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Relations
Regulator
Mechanism
target
score ℹ
+ PRKCAdown-regulates activity img/direct_inhibition.png phosphorylation RGS7 0.365
Identifier Residue Sequence Organism Cell Line
SIGNOR-263165 in vitro
pmid sentence
TNF-α rapidly increases the concentration of functionally active RGS7 protein through two mechanisms. TNF-induced dephosphorylation of serine 434 liberates RGS7 from 14-3-3 binding and inhibition. , PKC α catalyzes the incorporation of phosphate into a truncation of RGS7 fused to maltose-binding protein (MBP.RGS7315–469).
Publications: 1 Organism: In Vitro
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