Summary

Name SMARCA4
Full Name Transcription activator BRG1
Synonyms ATP-dependent helicase SMARCA4, BRG1-associated factor 190A, BAF190A, Mitotic growth and transcription activator, Protein BRG-1, Protein brahma homolog 1, SNF2-beta, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 | BAF190A, BRG1, SNF2B, SNF2L4
Primary ID P51532
Links - -
Type protein
Relations 13
Function Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1. Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). Binding to RNAs including lncRNA Evf2 leads to inhibition of SMARCA4 ATPase and chromatin remodeling activities (By similarity).

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Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination SMARCA4 0.339
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png binding TERT 0.766
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABCG2 0.309
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Embryonic stem cell-specific SWI/SNF 0.761
Publications: 1 Organism: Mus Musculus
+ form complex img/form-complex.png binding SWI/SNF ACTL6B varian 0.831
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SMARCC2 0.938
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Brain-specific SWI/SNF SMARCA4 variant 0.858
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ form complex img/form-complex.png binding Muscle cell-specific SWI/SNF SMARCA4 variant 0.865
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png binding SMARCA4 0.542
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding SWI/SNF complex 0.913
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ZEB1 0.413
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SMARCC1 0.949
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SMARCA4 0.942
Publications: 1 Organism: Homo Sapiens