3.0
Summary
| Name |  MNAT1View Modifications |
| Full Name | CDK-activating kinase assembly factor MAT1 |
| Synonyms | CDK7/cyclin-H assembly factor, Cyclin-G1-interacting protein, Menage a trois, RING finger protein 66, RING finger protein MAT1, p35, p36 | CAP35, MAT1, RNF66 |
| Primary ID | P51948 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MNAT1 | up-regulates activity 
phosphorylation
|
ESR1 | 0.408 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Ub:E2 | up-regulates activity
ubiquitination
|
MNAT1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MNAT1 | form complex 
binding
|
CAK complex | 0.945 |
| Publications: | 1 | Organism: | Homo Sapiens | |